(Q33402322)

26 July 2017

title

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages (English)

1 reference

26 July 2017

T Kodama

1

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author name string

H Hikita

2

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26 July 2017

T Kawaguchi

3

1 reference

26 July 2017

M Shigekawa

4

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26 July 2017

S Shimizu

5

1 reference

26 July 2017

Y Hayashi

6

1 reference

26 July 2017

W Li

7

1 reference

26 July 2017

T Miyagi

8

1 reference

26 July 2017

A Hosui

9

1 reference

26 July 2017

T Tatsumi

10

1 reference

26 July 2017

T Kanto

11

1 reference

26 July 2017

N Hiramatsu

12

1 reference

26 July 2017

K Kiyomizu

13

1 reference

26 July 2017

S Tadokoro

14

1 reference

26 July 2017

Y Tomiyama

15

1 reference

26 July 2017

N Hayashi

16

1 reference

26 July 2017

T Takehara

17

1 reference

26 July 2017

publication date

13 July 2012

1 reference

Cell Death & Differentiation

26 July 2017

published in

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26 July 2017

volume

19

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26 July 2017

issue

11

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26 July 2017

page(s)

1856-1869

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describes a project that uses

26 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3469054/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/cdd.2012.88

0 references

cites work

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Increases in p53 expression induce CTGF synthesis by mouse and human hepatocytes and result in liver fibrosis in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Life and death during hematopoietic differentiation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Myeloid cell leukemia-1 as a therapeutic target

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Megakaryocyte development and platelet production.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

The molecular mechanisms that control thrombopoiesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

A gain-of-function mutation of JAK2 in myeloproliferative disorders

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

The Bcl2 family: regulators of the cellular life-or-death switch

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Mcl-1 deficiency results in peri-implantation embryonic lethality

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Differences in platelet alpha-granule release between normals and immune thrombocytopenic patients and between young and old platelets.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Growth and differentiation of a human megakaryoblastic cell line, CMK.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Physiological functions of platelets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3469054

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

28 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Programmed anuclear cell death delimits platelet life span.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Life and death partners: apoptosis, autophagy and the cross-talk between them

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

BCL2 family in DNA damage and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

21 January 2018

Reticulated platelets.

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Transgenic expression of JAK2V617F causes myeloproliferative disorders in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Myeloproliferative neoplasm induced by constitutive expression of JAK2V617F in knock-in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCDD.2012.88

Deficiency in the anti-apoptotic protein A1-a results in a diminished acute inflammatory response

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22790873

12 December 2020

inferred from PubMed ID database lookup

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22790873

12 December 2020

inferred from PubMed ID database lookup

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22790873

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/CDD.2012.88

1 reference

26 July 2017

1 reference

26 July 2017

1 reference