(Q36734942)

16 August 2017

1 reference

title

Myeloid cell leukemia-1 as a therapeutic target (English)

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16 August 2017

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Richard M Pope

2

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author name string

Arthur M Mandelin

series ordinal

1

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PubMed ID

17298294

16 August 2017

language of work or name

English

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publication date

1 March 2007

1 reference

Expert Opinion on Therapeutic Targets

16 August 2017

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16 August 2017

11

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16 August 2017

363-373

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16 August 2017

3

1 reference

A blast from the past: clearance of apoptotic cells regulates immune responses.

16 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

21 January 2018

At the gates of death.

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

The pathophysiology of mitochondrial cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Life in the balance: how BH3-only proteins induce apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Myeloid cell factor-1 is a critical survival factor for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Serine phosphorylation of STAT3 is essential for Mcl-1 expression and macrophage survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mcl-1 is required for Akata6 B-lymphoma cell survival and is converted to a cell death molecule by efficient caspase-mediated cleavage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Modulating the bcl-2 family of apoptosis suppressors for potential therapeutic benefit in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Potentiation of the lethality of the histone deacetylase inhibitor LAQ824 by the cyclin-dependent kinase inhibitor roscovitine in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Imatinib spells BAD news for Bcr/abl-positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Apoptosis and melanoma: molecular mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mcl-1 antisense therapy chemosensitizes human melanoma in a SCID mouse xenotransplantation model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Enhanced killing of melanoma cells by simultaneously targeting Mcl-1 and NOXA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Mcl-1 is a novel therapeutic target for human sarcoma: synergistic inhibition of human sarcoma xenotransplants by a combination of mcl-1 antisense oligonucleotides with low-dose cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Apoptosis in rheumatoid arthritis: friend or foe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Apoptosis as a therapeutic tool in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cdelta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.11.3.363

10.1517/14728222.11.3.363

21 January 2018

Identifiers

DOI

1 reference

16 August 2017

1 reference

PubMed ID

17298294