(Q44598662)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14513048%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

title

Bisindolylmaleimide IX is a potent inducer of apoptosis in chronic lymphocytic leukaemic cells and activates cleavage of Mcl-1 (English)

1 reference

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19 December 2019

0 references

1 reference

3

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19 December 2019

author name string

R T Snowden

series ordinal

1

1 reference

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19 December 2019

X-M Sun

series ordinal

2

1 reference

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19 December 2019

G M Cohen

series ordinal

4

1 reference

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19 December 2019

language of work or name

1 reference

1 October 2003

1 reference

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19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14513048%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

volume

17

1 reference

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19 December 2019

issue

10

1 reference

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19 December 2019

page(s)

1981-1989

1 reference

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2403088

19 December 2019

exact match

0 references

cites work

Update on the biology of chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Death receptors: signaling and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Caspases: the executioners of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Apoptotic death sensor: an organelle's alter ego?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The proteasome: a novel target for cancer chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Elevated Bcl-2/Bax are a consistent feature of apoptosis resistance in B-cell chronic lymphocytic leukaemia and are correlated with in vivo chemoresistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Staurosporine analogues - pharmacological toys or useful antitumour agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Identification of PKC-isoform-specific biological actions using pharmacological approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Proteasome inhibitor-induced apoptosis of B-chronic lymphocytic leukaemia cells involves cytochrome c release and caspase activation, accompanied by formation of an approximately 700 kDa Apaf-1 containing apoptosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Mitochondria as the central control point of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Breaking the mitochondrial barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

IAP proteins: blocking the road to death's door

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The protective effect of phorbol esters on Fas-mediated apoptosis in T cells. Transcriptional and postranscriptional regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Myeloid cell factor-1 is a critical survival factor for multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Conversion of Bcl-2 to a Bax-like death effector by caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

inferred from DOI database lookup

7 January 2021

based on heuristic

The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

inferred from DOI database lookup

7 January 2021

based on heuristic

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403088

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.LEU.2403088

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14513048%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference