(Q33412553)

English

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199 (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Delphine Mérino

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Mary Ann Anderson

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Philippe Bouillet

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Andrew W. Roberts

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

author name string

S P Glaser

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

publication date

9 January 2014

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

28

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1207-1215

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

https://scigraph.springernature.com/pub.10.1038/leu.2014.1

0 references

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

p53 in health and disease

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

BCL-2 family antagonists for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Substantial susceptibility of chronic lymphocytic leukemia to BCL2 inhibition: results of a phase I study of navitoclax in patients with relapsed or refractory disease

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Programmed anuclear cell death delimits platelet life span.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Rapid generation of inducible mouse mutants

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bclx regulates the survival of double-positive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Apoptosis therapy: driving cancers down the road to ruin

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

ABT-199: taking dead aim at BCL-2

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

2 references

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

ABT-199, a new Bcl-2-specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Immunohistochemical double-hit score is a strong predictor of outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Overcoming blocks in apoptosis with BH3-mimetic therapy in haematological malignancies.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.1

21 January 2018

Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 family proteins are essential for platelet survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24402163

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2014.1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24402163%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q33412553&oldid=1978974123"