(Q33418637)

26 July 2017

1 reference

title

Antisense oligonucleotide therapies: the promise and the challenges from a toxicologic pathologist's perspective (English)

1 reference

26 July 2017

Kendall S Frazier

1

1 reference

PubMed ID

25385330

26 July 2017

language of work or name

English

0 references

publication date

9 November 2014

1 reference

26 July 2017

Toxicologic Pathology

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26 July 2017

43

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26 July 2017

1

1 reference

26 July 2017

78-89

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Role of Toll-like receptors in antisense and siRNA [corrected].

26 July 2017

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Unique O-methoxyethyl ribose-DNA chimeric oligonucleotide induces an atypical melanoma differentiation-associated gene 5-dependent induction of type I interferon response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Newly identified CpG ODNs, M5-30 and M6-395, stimulate mouse immune cells to secrete TNF-alpha and enhance Th1-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Antisense oligonucleotide-based therapeutics for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Proliferative and nonproliferative lesions of the rat and mouse urinary system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Species-specific inflammatory responses as a primary component for the development of glomerular lesions in mice and monkeys following chronic administration of a second-generation antisense oligonucleotide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Crosstalk pathways between Toll-like receptors and the complement system

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

A microRNA in a multiple-turnover RNAi enzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Antisense properties of peptide nucleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Evaluation of the renal effects of an antisense phosphorothioate oligodeoxynucleotide in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Synthetic oligonucleotides: the development of antisense therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Silencing of microRNA families by seed-targeting tiny LNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Stimulation of the immune system by therapeutic antisense oligodeoxynucleotides and small interfering RNAs via nucleic acid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Acute kidney injury during therapy with an antisense oligonucleotide directed against PCSK9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Targeted nanoparticles enhanced flow electroporation of antisense oligonucleotides in leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0192623314551840

21 January 2018

Identifiers

DOI

10.1177/0192623314551840

1 reference

26 July 2017

1 reference

PubMed ID

25385330