(Q33485591)

27 July 2017

title

An in silico study of the molecular basis of B-RAF activation and conformational stability (English)

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27 July 2017

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Filip F Fratev

1

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author name string

Svava Osk Jónsdóttir

series ordinal

2

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27 July 2017

publication date

22 July 2009

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27 July 2017

published in

BMC Structural Biology

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27 July 2017

volume

9

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27 July 2017

page(s)

47

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Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

27 July 2017

cites work

1 reference

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BRAF(E600) in benign and malignant human tumours

21 June 2018

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Molecular recognition of protein kinase binding pockets for design of potent and selective kinase inhibitors

21 June 2018

1 reference

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Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

21 June 2018

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Biochemical and molecular characterization of the novel BRAF(V599Ins) mutation detected in a classic papillary thyroid carcinoma.

21 June 2018

1 reference

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V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

21 June 2018

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Scalable molecular dynamics with NAMD

21 June 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 June 2018

1 reference

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Mutations of the BRAF gene in human cancer

21 June 2018

1 reference

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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 June 2018

1 reference

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Comparative protein structure modeling of genes and genomes

21 June 2018

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21 June 2018

The Protein Data Bank

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VMD: visual molecular dynamics

21 June 2018

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Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

21 June 2018

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Molecular basis of inactive B-RAF(WT) and B-RAF(V600E) ligand inhibition, selectivity and conformational stability: an in silico study

21 June 2018

1 reference

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Molecular basis explanation for imatinib resistance of BCR-ABL due to T315I and P-loop mutations from molecular dynamics simulations

31 October 2018

1 reference

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Switching on kinases: oncogenic activation of BRAF and the PDGFR family

31 October 2018

1 reference

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RAS oncogenes: the first 30 years.

31 October 2018

1 reference

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VEGA: a versatile program to convert, handle and visualize molecular structure on Windows-based PCs.

31 October 2018

1 reference

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The Eleventh Datta Lecture. The structural basis for substrate recognition and control by protein kinases

31 October 2018

1 reference

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31 October 2018

Identifiers

DOI

10.1186/1472-6807-9-47

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Dimensions Publication ID

27 July 2017

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27 July 2017

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