(Q36921234)

17 August 2017

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title

BRAF(E600) in benign and malignant human tumours (English)

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17 August 2017

Michaloglou C

1

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17 August 2017

Vredeveld LC

series ordinal

2

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17 August 2017

Mooi WJ

series ordinal

3

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17 August 2017

Peeper DS

series ordinal

4

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17 August 2017

language of work or name

English

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publication date

27 August 2007

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17 August 2017

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17 August 2017

27

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17 August 2017

877-895

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17 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1210704

17 August 2017

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cites work

Microcarcinoma of the thyroid

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Normal human fibroblasts are resistant to RAS-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Human melanocyte senescence and melanoma susceptibility genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Molecular regulation of melanocyte senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Structure and biological activity of human homologs of the raf/mil oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF gene is somatically mutated but does not make a major contribution to malignant melanoma susceptibility: the Italian Melanoma Intergroup Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Malignant melanoma: genetics and therapeutics in the genomic era.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mechanisms of regulating the Raf kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Use of human tissue to assess the oncogenic activity of melanoma-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Alterations of the BRAF gene in thyroid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Exon 15 BRAF mutations are uncommon in melanomas arising in nonsun-exposed sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Tumour biology: senescence in premalignant tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The power and the promise of oncogene-induced senescence markers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

A negative feedback signaling network underlies oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Somatic activation of KIT in distinct subtypes of melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Distinct sets of genetic alterations in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Activated B-RAF is an Hsp90 client protein that is targeted by the anticancer drug 17-allylamino-17-demethoxygeldanamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF alterations are associated with complex mutational profiles in malignant melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

New insight into BRAF mutations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Activated BRAF targets proximal colon tumors with mismatch repair deficiency and MLH1 inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Guilty as charged: B-RAF is a human oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Serrated pathway and APC (conventional)-type colorectal polyps: molecular-morphologic correlations, genetic pathways, and implications for classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The Brn-2 transcription factor links activated BRAF to melanoma proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The role of B-RAF in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Melanoma biology and new targeted therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The melanocyte differentiation program predisposes to metastasis after neoplastic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The gene expression signatures of melanoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Cellular senescence in aging primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Germline p16 mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

B-raf, a new member of the raf family, is activated by DNA rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Heat shock protein 90 as a molecular target for cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

No Evidence for BRAF as a melanoma/nevus susceptibility gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF polymorphisms and risk of melanocytic neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

B-RAF is a therapeutic target in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Pathogenetic mechanisms in thyroid follicular-cell neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Use of mitogenic cascade blockers for treatment of C-Raf induced lung adenoma in vivo: CI-1040 strongly reduces growth and improves lung structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

ERK and PI3K negatively regulate STAT-transcriptional activities in human melanoma cells: implications towards sensitization to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Absence of exon 15 BRAF germline mutations in familial melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutational analysis of the ARAF gene in human cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The p53 tumour suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

MITF: master regulator of melanocyte development and melanoma oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Cooperating oncogenes converge to regulate cyclin/cdk complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Determinants of BRAF mutations in primary melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Integrating signals from RTKs to ERK/MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Raf-1 is the predominant Raf isoform that mediates growth factor-stimulated growth in ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Combined targeting of MAPK and AKT signalling pathways is a promising strategy for melanoma treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Polymorphisms of the BRAF gene predispose males to malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Redox regulation in human melanocytes and melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAFE600-associated senescence-like cell cycle arrest of human naevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Senescence and serration: a new twist to an old tale

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Regulation of human skin pigmentation and responses to ultraviolet radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Synergistic inhibition of human melanoma proliferation by combination treatment with B-Raf inhibitor BAY43-9006 and mTOR inhibitor Rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Oncogene-induced cell senescence--halting on the road to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutational analysis of the BRAF gene in human congenital and dysplastic melanocytic naevi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Microarray expression profiling in melanoma reveals a BRAF mutation signature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

High frequency of BRAF mutations in nevi

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Effects on proliferation and melanogenesis by inhibition of mutant BRAF and expression of wild-type INK4A in melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

KLF4, p21 and context-dependent opposing forces in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The p16INK4a/CDKN2A tumor suppressor and its relatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Regulation and role of Raf-1/B-Raf heterodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF is a therapeutic target in aggressive thyroid carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Raf kinases: oncogenesis and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutually exclusive NRASQ61R and BRAFV600E mutations at the single-cell level in the same human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Inhibitors of the HSP90 molecular chaperone: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Senescence and immortalization: role of telomeres and telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

The INK4a/ARF network in tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

BRAF mutation predicts sensitivity to MEK inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Deregulated Akt3 activity promotes development of malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Cancer genetics and drug discovery in the zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Significant impact of promoter hypermethylation and the 540 C>T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Skin colour and skin cancer - MC1R, the genetic link

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

p16(Ink4a) in melanocyte senescence and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Loss of expression of the p16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

B-RAF mutations in the etiopathogenesis, diagnosis, and prognosis of thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210704

Acute lymphoblastic leukaemia in a patient with cardiofaciocutaneous syndrome

21 January 2018

1 reference

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The transcription network regulating melanocyte development and melanoma

21 January 2018

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The tumor-suppressive functions of the human INK4A locus

21 January 2018

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

21 January 2018

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Cancer. Addiction to oncogenes--the Achilles heal of cancer

21 January 2018

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The RAF proteins take centre stage

21 January 2018

1 reference

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Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation

21 January 2018

1 reference

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BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

21 January 2018

1 reference

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Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis

21 January 2018

1 reference

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The relation between melanocortin 1 receptor (MC1R) variation and the generation of phenotypic diversity in the cutaneous response to ultraviolet radiation

21 January 2018

1 reference

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Induction of beta3-integrin gene expression by sustained activation of the Ras-regulated Raf-MEK-extracellular signal-regulated kinase signaling pathway

21 January 2018

1 reference

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BRAF mutation in thyroid cancer

21 January 2018

1 reference

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Mutations of the BRAF gene in benign and malignant melanocytic lesions

21 January 2018

1 reference

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Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

21 January 2018

1 reference

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Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

1 reference

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Lack of association between BRAF V600E mutation and mitogen-activated protein kinase activation in papillary thyroid carcinoma.

21 January 2018

1 reference

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Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

21 January 2018

1 reference

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Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis

21 January 2018

1 reference

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Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

21 January 2018

1 reference

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Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

21 January 2018

1 reference

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Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway

21 January 2018

1 reference

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7 January 2021

Cooperative effects of INK4a and ras in melanoma susceptibility in vivo

1 reference

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7 January 2021

Oncogenic AKAP9-BRAF fusion is a novel mechanism of MAPK pathway activation in thyroid cancer

1 reference

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7 January 2021

BRAF copy number gains in thyroid tumors detected by fluorescence in situ hybridization

1 reference

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7 January 2021

BRAF Mutation in Papillary Thyroid Carcinoma

1 reference

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7 January 2021

Distinct phenotypic changes between the superficial and deep component of giant congenital melanocytic naevi: a rationale for curettage

1 reference

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7 January 2021

Overexpression of plasminogen activator inhibitor type-1 in senescent fibroblasts from normal subjects and those with Werner syndrome

1 reference

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7 January 2021

Mutations of BRAF and KRAS precede the development of ovarian serous borderline tumors

1 reference

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7 January 2021

Oncogenic BRAF is required for tumor growth and maintenance in melanoma models

1 reference

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7 January 2021

Proliferative activity of primary cutaneous melanocytic tumours

1 reference

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7 January 2021

MC1R germline variants confer risk for BRAF-mutant melanoma

1 reference

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7 January 2021

BRAFMutations Are Not a Major Event in Post-Chernobyl Childhood Thyroid Carcinomas

1 reference

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7 January 2021

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

1 reference

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7 January 2021

p53 immunoreactivity in human malignant melanoma and dysplastic naevi

1 reference

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7 January 2021

Exclusion of BRAFV599E as a melanoma susceptibility mutation

1 reference

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7 January 2021

Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity.

1 reference

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7 January 2021

Epigenetic silencing of the PTEN gene in melanoma

1 reference

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7 January 2021

Distinguishing Costello versus cardio-facio-cutaneous syndrome: BRAF mutations in patients with a Costello phenotype

1 reference

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7 January 2021

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC

1 reference

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7 January 2021

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

1 reference

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7 January 2021

Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas

1 reference

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7 January 2021

Overexpression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in human cutaneous malignant melanoma

1 reference

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7 January 2021

Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi

1 reference

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7 January 2021

Immunohistochemical detection of CDK4 and p16INK4 proteins in cutaneous malignant melanoma

1 reference

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7 January 2021

BRAF and c-kit gene copy number in mutation-positive malignant melanoma

1 reference

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7 January 2021

BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status

1 reference

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7 January 2021

Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs

1 reference

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7 January 2021

Senescence of human fibroblasts induced by oncogenic Raf.

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1210704

1 reference

17 August 2017

1 reference