(Q40646165)

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p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression.

scientific article published on May 2003

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scholarly article

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3 November 2019

p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression (English)

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3 November 2019

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3 November 2019

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Elena V Sviderskaya

1

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3 November 2019

Vanessa C Gray-Schopfer

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3 November 2019

Simon P Hill

3

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3 November 2019

Tracy J Evans-Whipp

5

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3 November 2019

Jane Bond

6

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3 November 2019

Lucy Hill

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3 November 2019

Veronique Bataille

8

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3 November 2019

Gordon Peters

9

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3 November 2019

David Kipling

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3 November 2019

David Wynford-Thomas

11

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3 November 2019

Dorothy C Bennett

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3 November 2019

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1 May 2003

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3 November 2019

Journal of the National Cancer Institute

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3 November 2019

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3 November 2019

723-732

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3 November 2019

The INK4A/ARF locus and its two gene products

1 reference

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21 January 2018

p16(MTS-1/CDKN2/INK4a) in cancer progression

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21 January 2018

The INK4a/ARF network in tumour suppression

1 reference

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21 January 2018

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

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21 January 2018

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1 reference

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21 January 2018

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

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21 January 2018

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

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21 January 2018

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

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21 January 2018

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

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21 January 2018

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

1 reference

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21 January 2018

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 reference

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21 January 2018

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

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21 January 2018

The age of cancer

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21 January 2018

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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21 January 2018

Identification of human tumour suppressor genes by monochromosome transfer: rapid growth-arrest response mapped to 9p21 is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16INK4A).

1 reference

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21 January 2018

Role of p14(ARF) in replicative and induced senescence of human fibroblasts

1 reference

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21 January 2018

Role of the INK4a locus in tumor suppression and cell mortality.

1 reference

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21 January 2018

Terminal differentiation and senescence in the human melanocyte: repression of tyrosine-phosphorylation of the extracellular signal-regulated kinase 2 selectively defines the two phenotypes

1 reference

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21 January 2018

The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells

1 reference

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21 January 2018

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin

1 reference

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21 January 2018

Molecular regulation of melanocyte senescence

1 reference

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21 January 2018

Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts

1 reference

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21 January 2018

Homozygous germline mutation of CDKN2A/p16 and glucose-6-phosphate dehydrogenase deficiency in a multiple melanoma case

1 reference

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21 January 2018

Telomere states and cell fates

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21 January 2018

Extension of life-span by introduction of telomerase into normal human cells

1 reference

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21 January 2018

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

1 reference

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21 January 2018

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

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21 January 2018

Complementation of hypopigmentation in p-mutant (pink-eyed dilution) mouse melanocytes by normal human P cDNA, and defective complementation by OCA2 mutant sequences

1 reference

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21 January 2018

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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21 January 2018

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges

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21 January 2018

Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

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21 January 2018

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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21 January 2018

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

1 reference

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21 January 2018

PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum

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Reduced growth factor requirements and accelerated cell-cycle kinetics in adult human melanocytes transformed with SV40 large T antigen.

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

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21 January 2018

p16(Ink4a) in melanocyte senescence and differentiation.

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21 January 2018

Mutations of the BRAF gene in human cancer

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Model predicting survival in stage I melanoma based on tumor progression

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Protein tyrosine kinases in malignant melanoma

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Update on genetic events in the pathogenesis of melanoma

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Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds

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