(Q33530722)

27 July 2017

title

NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3 (English)

1 reference

27 July 2017

0 references

Erika A Bach

7

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author name string

Byung-Hak Kim

1

1 reference

27 July 2017

Jun-Goo Jee

2

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27 July 2017

Chang-Hong Yin

3

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27 July 2017

Claudio Sandoval

4

1 reference

27 July 2017

Somasundaram Jayabose

5

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27 July 2017

Daisuke Kitamura

6

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27 July 2017

Gyeong-Hun Baeg

8

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27 July 2017

publication date

11 February 2010

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27 July 2017

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27 July 2017

volume

9

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27 July 2017

page(s)

36

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MS-1020 is a novel small molecule that selectively inhibits JAK3 activity

27 July 2017

cites work

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LS104, a non-ATP-competitive small-molecule inhibitor of JAK2, is potently inducing apoptosis in JAK2V617F-positive cells

21 June 2018

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21 June 2018

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Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3.

21 June 2018

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21 June 2018

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21 June 2018

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Identification of a constitutively active mutant of JAK3 by retroviral expression screening

21 June 2018

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Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells

21 June 2018

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21 June 2018

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Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells

21 June 2018

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21 June 2018

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Activation status of the JAK/STAT3 pathway in mantle cell lymphoma

21 June 2018

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Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog

21 June 2018

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Jak3, severe combined immunodeficiency, and a new class of immunosuppressive drugs.

21 June 2018

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Is JAK3 a new drug target for immunomodulation-based therapies?

21 June 2018

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Src family kinases, key regulators of signal transduction

21 June 2018

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A new modality for immunosuppression: targeting the JAK/STAT pathway

21 June 2018

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Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma Cells

21 June 2018

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21 June 2018

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21 June 2018

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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 June 2018

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Differential effect of IL-4 and IL-13 on CD44 expression in the Burkitt's lymphoma B cell line BL30/B95-8 and in Epstein-Barr virus (EBV) transformed human B cells: loss of IL-13 receptors on Burkitt's lymphoma B cells.

21 June 2018

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Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions

21 June 2018

1 reference

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Automated docking of flexible ligands: applications of AutoDock

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Requirement of nuclear prolactin for interleukin-2--stimulated proliferation of T lymphocytes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2830973

Defective lymphoid development in mice lacking Jak3

31 October 2018

1 reference

12 December 2020

Regulation of cell growth by IL-2: role of STAT5 in protection from apoptosis but not in cell cycle progression

1 reference

12 December 2020

Validating Stat3 in cancer therapy

1 reference

12 December 2020

JAK3 mutations occur in acute megakaryoblastic leukemia both in Down syndrome children and non-Down syndrome adults

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-4598-9-36

1 reference

Dimensions Publication ID

27 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-9-36

9 September 2019

1 reference

27 July 2017

1 reference