(Q33597113)

28 July 2017

title

Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis (English)

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28 July 2017

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Cynthia Davidson

3

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Timothy D Le Cras

object named as

Timothy D Le Cras

1

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author name string

Thomas R Korfhagen

2

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28 July 2017

Stephanie Schmidt

4

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28 July 2017

Matthew Fenchel

5

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28 July 2017

Machiko Ikegami

6

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28 July 2017

Jeffrey A Whitsett

7

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28 July 2017

William D Hardie

8

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28 July 2017

language of work or name

English

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publication date

30 December 2009

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The American Journal of Pathology

28 July 2017

published in

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28 July 2017

volume

176

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28 July 2017

issue

2

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28 July 2017

page(s)

679-686

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describes a project that uses

28 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2808075/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

14 July 2018

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Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis

14 July 2018

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Role of platelet-derived growth factors in physiology and medicine

14 July 2018

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Conditional deletion of Pten causes bronchiolar hyperplasia

14 July 2018

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Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy

14 July 2018

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Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis

14 July 2018

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Semaphorin 7A plays a critical role in TGF-beta1-induced pulmonary fibrosis

14 July 2018

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14 July 2018

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PTEN regulates fibroblast elimination during collagen matrix contraction

14 July 2018

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Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)

14 July 2018

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The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

14 July 2018

1 reference

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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.

14 July 2018

1 reference

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

14 July 2018

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Stat-3 is required for pulmonary homeostasis during hyperoxia

14 July 2018

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Integrin alpha4beta1 regulates migration across basement membranes by lung fibroblasts: a role for phosphatase and tensin homologue deleted on chromosome 10

14 July 2018

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Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor α-converting Enzyme and Amphiregulin

14 July 2018

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ErbB-4: mechanism of action and biology

14 July 2018

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The deaf and the dumb: the biology of ErbB-2 and ErbB-3

14 July 2018

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14 July 2018

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Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

14 July 2018

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14 July 2018

1 reference

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14 July 2018

1 reference

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Production of epidermal growth factor related ligands in tumorigenic and benign human lung epithelial cells

14 July 2018

1 reference

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Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808075

Expression of c-erbB receptors and ligands in human bronchial mucosa

14 July 2018

1 reference

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Improved Movat pentachrome stain

14 July 2018

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Targeting RAS and PI3K in lung cancer.

14 July 2018

1 reference

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EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis

30 October 2018

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Will kinase inhibitors have a dark side?

30 October 2018

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Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

30 October 2018

1 reference

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Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha.

30 October 2018

1 reference

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Role of neuregulin-1 beta in the developing lung

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808075

Conditional expression of fibroblast growth factor-7 in the developing and mature lung.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2808075

A computer-controlled research ventilator for small animals: design and evaluation

30 October 2018

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12 December 2020

Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha

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12 December 2020

An essential role for ectodomain shedding in mammalian development

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12 December 2020

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12 December 2020

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12 December 2020

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Identifiers

DOI

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28 July 2017

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28 July 2017

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