(Q33606444)

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Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

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28 July 2017

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

author name string

Clifford R Elcombe

1

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Europe PubMed Central

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28 July 2017

Richard C Peffer

2

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28 July 2017

Douglas C Wolf

3

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Europe PubMed Central

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28 July 2017

Jason Bailey

4

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Europe PubMed Central

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28 July 2017

Remi Bars

5

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Europe PubMed Central

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28 July 2017

David Bell

6

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Europe PubMed Central

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28 July 2017

Russell C Cattley

7

1 reference

Europe PubMed Central

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28 July 2017

Stephen S Ferguson

8

1 reference

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28 July 2017

David Geter

9

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28 July 2017

Amber Goetz

10

1 reference

Europe PubMed Central

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28 July 2017

Jay I Goodman

11

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Europe PubMed Central

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28 July 2017

Susan Hester

12

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Europe PubMed Central

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28 July 2017

Abigail Jacobs

13

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Europe PubMed Central

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28 July 2017

Curtis J Omiecinski

14

1 reference

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28 July 2017

Rita Schoeny

15

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28 July 2017

Wen Xie

16

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28 July 2017

Brian G Lake

17

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28 July 2017

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publication date

4 November 2013

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28 July 2017

Critical Reviews in Toxicology

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28 July 2017

44

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28 July 2017

1

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28 July 2017

64-82

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Europe PubMed Central

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28 July 2017

Dose-response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop

1 reference

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Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

1 reference

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A review of epidemiological data on epilepsy, phenobarbital, and risk of liver cancer

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Multi-species analyses of direct activators of the constitutive androstane receptor

1 reference

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In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice

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An integrated functional genomic study of acute phenobarbital exposure in the rat

1 reference

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Oxidative stress and oxidative damage in carcinogenesis

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Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

1 reference

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Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

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Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk

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Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

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Inhibition and induction of human cytochrome P450 enzymes: current status

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The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver

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Gene expression profiling and differentiation assessment in primary human hepatocyte cultures, established hepatoma cell lines, and human liver tissues

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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

1 reference

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Nuclear receptors CAR and PXR in the regulation of hepatic metabolism

1 reference

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21 June 2018

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

1 reference

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21 June 2018

Drug-related hepatotoxicity

1 reference

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21 June 2018

Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor

1 reference

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Confounders in interpreting pathology for safety and risk assessment

1 reference

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PPARalpha agonist-induced rodent tumors: modes of action and human relevance

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A framework for human relevance analysis of information on carcinogenic modes of action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

The human relevance of information on carcinogenic modes of action: overview

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21 June 2018

Regulation of Drug Transporter Gene Expression by Nuclear Receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Functional and structural comparison of PXR and CAR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Disruption of gap junctions in toxicity and carcinogenicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Altered DNA methylation: a secondary mechanism involved in carcinogenesis

1 reference

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Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

1 reference

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21 June 2018

Cyproterone acetate: a genotoxic carcinogen?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Lack of phenobarbital-mediated promotion of hepatocarcinogenesis in connexin32-null mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

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Cell death and cell proliferation in the control of normal and neoplastic tissue growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

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The perturbation of apoptosis and mitosis by drugs and xenobiotics

1 reference

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21 June 2018

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

21 June 2018

Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.

1 reference

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The quantitative distinction of hyperplasia from hypertrophy in hepatomegaly induced in the rat liver by phenobarbital

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Chemicals with carcinogenic activity in the rodent liver; mechanistic evaluation of human risk

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Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats

1 reference

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Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

1 reference

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Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats

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Carcinogenicity of cyproterone acetate in the mouse

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Reversibility of promoter induced hepatic focal lesion growth in mice

1 reference

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Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis

1 reference

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The paradoxical lack of interspecies correlation between plasma concentrations and chemical carcinogenicity

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Cell proliferation in the liver and thyroid of C57Bl/10J mice after dietary administration of chlordane

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Increased susceptibility of livers of aged F344/NCr rats to the effects of phenobarbital on the incidence, morphology, and histochemistry of hepatocellular foci and neoplasms

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Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters

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Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver

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Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents

1 reference

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21 June 2018

Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters.

1 reference

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Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication.

1 reference

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21 June 2018

Induction of a pleiotropic response by phenobarbital and related compounds. Response in various inbred strains of rats, response in various species and the induction of aldehyde dehydrogenase in Copenhagen rats

1 reference

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1 reference

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21 June 2018

Long-term administration of DDT or phenobarbital-Na in Wistar rats

1 reference

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The effect of prolonged sodium phenobarbitone treatment on hepatic xenobiotic metabolism and the urinary excretion of metabolites of the D-glucuronic acid pathway in the rat

1 reference

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21 June 2018

Liver size and indices of drug metabolism in epileptics

1 reference

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21 June 2018

Long-term effects of phenobarbitone-Na on male Fischer rats

1 reference

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21 June 2018

Anticonvulsant drugs and cancer. A cohort study in patients with severe epilepsy

1 reference

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21 June 2018

Diethanolamine and phenobarbital produce an altered pattern of methylation in GC-rich regions of DNA in B6C3F1 mouse hepatocytes similar to that resulting from choline deficiency

1 reference

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21 January 2018

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Mode of action in relevance of rodent liver tumors to human cancer risk.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Orphan nuclear receptor constitutive active/androstane receptor-mediated alterations in DNA methylation during phenobarbital promotion of liver tumorigenesis.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Rapid development of hepatocellular neoplasms in aging male C3H/HeNCr mice given phenobarbital

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Absence of DNA adduct formation by phenobarbital, polychlorinated biphenyls, and chlordane in mouse liver using the 32P-postlabeling assay.

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

1 reference

https://api.crossref.org/works/10.3109%2F10408444.2013.835786

21 January 2018

Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

30 October 2018

Modulation of gap junctional intercellular communication in rodent, monkey and human hepatocyte by nongenotoxic compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

30 October 2018

Colocalized alterations in connexin32 and cytochrome P450IIB1/2 by phenobarbital and related liver tumor promoters

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

30 October 2018

Morphological classification of mouse liver tumors based on biological characteristics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

30 October 2018

Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4019974

30 October 2018

Induction of cytochromes P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatonecrosis and cholangitis related to long-term phenobarbital therapy: An autopsy report of two patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatocellular adenoma associated with long-term exposure to phenobarbital: a paediatric case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression analysis reveals chemical-specific profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brief communication: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term studies on chemically induced liver enlargement in the rat. I. Sustained induction of microsomal enzymes with absence of liver damage on feeding phenobarbitone or butylated hydroxytoluene

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of phenobarbital and diphenylhydantoin on liver function and morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promotion of spontaneous preneoplastic cells in rat liver as a possible explanation of tumor production by nonmutagenic compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and partial purification of hamster microsomal cytochrome P-450 isoenzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenesis of dimethylnitrosamine-induced hepatocellular cancer in hamster liver and lack of enhancement by phenobarbital

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of phenobarbital inhibition of intercellular communication in mouse hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver damage in long-term anticonvulsant therapy: a serological and histological study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of liver microsomal cytochrome P450 in cynomolgus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of apoptosis in mouse hepatocytes and alteration of apoptosis by nongenotoxic carcinogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/24180433

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3109/10408444.2013.835786

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

ResearchGate publication ID

0 references

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