(Q43093199)

English

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

scientific article published on 19 April 2010

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20403969%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20403969%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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31 January 2020

Colin J Henderson

7

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31 January 2020

8

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31 January 2020

Clifford R Elcombe

9

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Clifford R Elcombe

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31 January 2020

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Jillian Ross

1

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31 January 2020

Simon M Plummer

2

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31 January 2020

Anja Rode

3

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31 January 2020

Conrad C Bower

5

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31 January 2020

Ortwin Vogel

6

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31 January 2020

publication date

19 April 2010

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31 January 2020

Toxicological Sciences

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31 January 2020

116

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31 January 2020

2

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31 January 2020

452-466

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31 January 2020

Prediction of rodent carcinogenesis: an evaluation of prechronic liver lesions as forecasters of liver tumors in NTP carcinogenicity studies

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Alternatively spliced isoforms of the human constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Retinoid X receptor-alpha-dependent transactivation by a naturally occurring structural variant of human constitutive androstane receptor (NR1I3).

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Hepatic peroxisome proliferation in rodents and its significance for humans

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Role of persistent, non-genotoxic tissue damage in rodent cancer and relevance to humans

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Cancer among epileptic patients exposed to anticonvulsant drugs

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Liver size and indices of drug metabolism in epileptics

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Induction of liver growth by xenobiotic compounds and other stimuli.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Nuclear receptors CAR and PXR in the regulation of hepatic metabolism

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFQ118

21 January 2018

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