(Q37557621)

21 August 2017

1 reference

title

Species differences in the hepatic effects of inducers of CYP2B and CYP4A subfamily forms: relationship to rodent liver tumour formation (English)

1 reference

21 August 2017

B G Lake

1

1 reference

21 August 2017

language of work or name

English

0 references

publication date

1 August 2009

1 reference

21 August 2017

1 reference

21 August 2017

volume

39

1 reference

21 August 2017

issue

8

1 reference

21 August 2017

page(s)

582-596

1 reference

Species-specific kinetics and zonation of hepatic DNA synthesis induced by ligands of PPARalpha

21 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparison of the acute and chronic mitogenic effects of the peroxisome proliferators methylclofenapate and clofibric acid in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of cytochrome P-450 in cultured rat hepatocytes. The heterogeneous localization of specific isoenzymes using immunocytochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Localization and differential induction of cytochrome P450IVA and acyl-CoA oxidase in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Hepatic peroxisome proliferation in rodents and its significance for humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Apoptosis in stages of mouse hepatocarcinogenesis: failure to counterbalance cell proliferation and to account for strain differences in tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Controlled death (apoptosis) of normal and putative preneoplastic cells in rat liver following withdrawal of tumor promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

No increase of apoptosis in regressing mouse liver after withdrawal of growth stimuli or food restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Disruption of gap junctions in toxicity and carcinogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Species differences in peroxisome proliferation; mechanisms and relevance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Molecular analysis of peroxisome proliferation in the hamster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Evaluating the human relevance of chemically induced animal tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The human relevance of information on carcinogenic modes of action: overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Enhancement of thyroid and hepatocarcinogenesis by 1,4-bis[2-(3,5- dichloropyridyloxy)]benzene in rats at doses that cause maximal induction of CYP2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Lack of effect of phenobarbital on hepatocellular carcinogenesis initiated by N-nitrosodiethylamine or methylazoxymethanol acetate in male Syrian golden hamsters

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

A cancer risk assessment of di(2-ethylhexyl)phthalate: application of the new U.S. EPA Risk Assessment Guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Hepatocellular DNA synthesis in rats given peroxisome proliferating agents: comparison of WY-14,643 to clofibric acid, nafenopin and LY171883.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Measurement of chemically induced cell proliferation in rodent liver and kidney: a comparison of 5-bromo-2'-deoxyuridine and [3H]thymidine administered by injection or osmotic pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Human health risk assessment for peroxisome proliferators: more than 30 years of research

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cell death and cell proliferation in the control of normal and neoplastic tissue growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The genetic toxicity of the peroxisome proliferator class of rodent hepatocarcinogen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative aspects of the mammalian cytochrome P450 IV gene family

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Peroxisome proliferators: paradigms and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cytochrome P-450 induction by clofibrate. Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The non-genotoxic hepatocarcinogen nafenopin suppresses rodent hepatocyte apoptosis induced by TGFbeta1, DNA damage and Fas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Quantitation of the cancer process in C57BL/6J, B6C3F1 and C3H/HeJ mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis, and apoptosis in rat and human hepatocyte cultures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cytochrome P-450 distribution in rat liver and the effect of sodium phenobarbitone administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of drug metabolism: species differences and toxicological relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cloning, tissue expression, and regulation of beagle dog CYP4A genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Evidence for and possible mechanisms of non-genotoxic carcinogenesis in rodent liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Suppression of mouse hepatocyte apoptosis by peroxisome proliferators: role of PPARalpha and TNFalpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea-pig liver in vivo nor in human hepatocytes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The perturbation of apoptosis and mitosis by drugs and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Mode of action in relevance of rodent liver tumors to human cancer risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Changes in global gene and protein expression during early mouse liver carcinogenesis induced by non-genotoxic model carcinogens oxazepam and Wyeth-14,643.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The peroxisome proliferator class of non-genotoxic hepatocarcinogens synergize with epidermal growth factor to promote clonal expansion of initiated rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than suppression of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of a pleiotropic response by phenobarbital and related compounds. Response in various inbred strains of rats, response in various species and the induction of aldehyde dehydrogenase in Copenhagen rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative effects of phthalate monoesters on gap junctional intercellular communication and peroxisome proliferation in rodent and primate hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative effects of dieldrin on hepatic ploidy, cell proliferation, and apoptosis in rodent liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

PPARalpha agonist-induced rodent tumors: modes of action and human relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative effects of phenobarbital, DDT, and lindane on mouse hepatocyte gap junctional intercellular communication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Dose dependence of phenobarbital promotion of preneoplastic hepatic lesions in F344 rats and B6C3F1 mice: effects on DNA synthesis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig, and marmoset

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor ex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

CYP induction-mediated drug interactions: in vitro assessment and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Species differences in ciprofibrate induction of hepatic cytochrome p450 4A1 and peroxisome proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

A framework for human relevance analysis of information on carcinogenic modes of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Functional and structural comparison of PXR and CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of alkoxyresorufin O-dealkylases, epoxide hydrolase, and liver weight gain: correlation with liver tumor-promoting potential in a series of barbiturates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Induction of cytochrome P-450 in the Norway rat, Rattus norvegicus, following exposure to potential environmental contaminants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cancer among epileptic patients exposed to anticonvulsant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Difference between guinea pig and rat in the liver peroxisomal response to equivalent plasmatic level of ciprofibrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Inhibition and induction of human cytochrome P450 (CYP) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Inhibition and induction of human cytochrome P450 enzymes: current status

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Effect of rodent hepatocarcinogenic peroxisome proliferators on fatty acyl-CoA oxidase, DNA synthesis, and apoptosis in cultured human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Liver size and indices of drug metabolism in epileptics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Comparative study of CYP2B induction in the liver of rats and mice by different compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Effects of clofibric acid on mRNA expression profiles in primary cultures of rat, mouse and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different hepatocyte populations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Fibrate treatment does not modify the expression of acyl coenzyme A oxidase in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Facilitated expression of adaptive responses to phenobarbital in putative pre-stages of liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Microsomal cytochrome P-452 induction and peroxisome proliferation by hypolipidaemic agents in rat liver. A mechanistic inter-relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Enhancement of dimethylnitrosamine-initiated hepatocarcinogenesis in hamsters by subsequent administration of carbon tetrachloride but not phenobarbital or p,p'-dichlorodiphenyltrichloroethane

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, -BHC and -BHC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Nuclear receptors CAR and PXR in the regulation of hepatic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: significance for species differences in response to PPs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250903098184

10.1080/00498250903098184

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference