(Q36485692)

14 August 2017

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title

CYP induction-mediated drug interactions: in vitro assessment and clinical implications (English)

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14 August 2017

Jiunn H Lin

1

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14 August 2017

publication date

26 May 2006

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14 August 2017

published in

Pharmaceutical Research

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14 August 2017

volume

23

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14 August 2017

issue

6

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14 August 2017

page(s)

1089-1116

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Functional analysis of the transcriptional promoter for the CYP1A1 gene

14 August 2017

cites work

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21 January 2018

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

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Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

21 January 2018

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

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Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

21 January 2018

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The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

21 January 2018

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Commentary: a physiological approach to hepatic drug clearance

21 January 2018

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The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

21 January 2018

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Induction of propranolol metabolism by rifampicin

21 January 2018

1 reference

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Influence of meso-caval shunt surgery on verapamil kinetics, bioavailability and response

21 January 2018

1 reference

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Codeine O-demethylation co-segregates with polymorphic debrisoquine hydroxylation

21 January 2018

1 reference

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Pharmacokinetics of codeine and its metabolites in Caucasian healthy volunteers: comparisons between extensive and poor hydroxylators of debrisoquine

21 January 2018

1 reference

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DNA strand cleavage as a sensitive assay for the production of hydroxyl radicals by microsomes: role of cytochrome P4502E1 in the increased activity after ethanol treatment

21 January 2018

1 reference

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Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450.

21 January 2018

1 reference

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Induction of cytochrome P450IA genes (CYP1A) by omeprazole in the human alimentary tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0277-7

Stimulatory effect of brussels sprouts and cabbage on human drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0277-7

Effect of pentobarbital on the disposition of alprenolol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0277-7

Interaction of chronic daily warfarin therapy and rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-006-0277-7

Drug-drug interaction mediated by inhibition and induction of P-glycoprotein

21 January 2018

1 reference

12 December 2020

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

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12 December 2020

Increased NADPH- and NADH-dependent production of superoxide and hydroxyl radical by microsomes after chronic ethanol treatment

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12 December 2020

Two-stage glucocorticoid induction of CYP3A23 through both the glucocorticoid and pregnane X receptors

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12 December 2020

Concentrations and effects of zopiclone are greatly reduced by rifampicin

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12 December 2020

Triazolam is ineffective in patients taking rifampin

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12 December 2020

Characterization and strain distribution pattern of the murine Ah receptor specified by the Ahd and Ahb-3 alleles

1 reference

12 December 2020

Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation.

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12 December 2020

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver

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12 December 2020

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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12 December 2020

Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction.

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12 December 2020

Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes

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12 December 2020

Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin

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12 December 2020

The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity

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12 December 2020

The glucocorticoid receptor is essential for induction of cytochrome P-4502B by steroids but not for drug or steroid induction of CYP3A or P-450 reductase in mouse liver.

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12 December 2020

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation

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12 December 2020

Induction of rat liver bilirubin-conjugating enzymes and glutathione S-transferase by rifampicin

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12 December 2020

Mechanisms of hepatotoxicity

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12 December 2020

Effects of dietary protein on theophylline pharmacokinetics and caffeine and aminopyrine breath tests

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12 December 2020

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

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12 December 2020

Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

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12 December 2020

Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1)

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12 December 2020

Interaction of rifampin and warfarin

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12 December 2020

Refinement of an in vitro cell model for cytochrome P450 induction

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12 December 2020

2,3,7,8-Tetrachlorodibenzo-p-dioxin: Potent anticarcinogenic activity in CD-1 mice

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12 December 2020

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

12 December 2020

Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain

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12 December 2020

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

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12 December 2020

Loss of analgesic effect of morphine due to coadministration of rifampin

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12 December 2020

The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.

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12 December 2020

Effect of rifampicin on the pharmacokinetics and pharmacodynamics of glimepiride

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12 December 2020

The effect of antipyrine and rifampin on the metabolism of diazepam.

1 reference

12 December 2020

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

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12 December 2020

Nuclear receptor CAR as a regulatory factor for the sexually dimorphic induction of CYB2B1 gene by phenobarbital in rat livers

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12 December 2020

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

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12 December 2020

Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat

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12 December 2020

The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin

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12 December 2020

A physiologically based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice

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12 December 2020

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

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12 December 2020

Tuberculosis in renal transplant recipients

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12 December 2020

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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12 December 2020

Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation

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12 December 2020

Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line

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12 December 2020

Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo

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12 December 2020

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

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12 December 2020

Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S. Goodman Lecture

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12 December 2020

CYP1A1: friend or foe?

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12 December 2020

Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of pefloxacin.

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12 December 2020

Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity

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12 December 2020

The use of human hepatocyte cultures to study the induction of cytochrome P-450.

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12 December 2020

Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice

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12 December 2020

Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice

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12 December 2020

Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin

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12 December 2020

Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine.

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12 December 2020

Polymorphisms in the human AH receptor

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12 December 2020

The high incidence of tuberculosis among renal transplant recipients in India

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12 December 2020

Regulation of cytochrome p450 by inflammatory mediators: why and how?

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12 December 2020

In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone

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12 December 2020

Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms

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12 December 2020

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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12 December 2020

Effect of rifampicin on the mouse hepatic mixed-function oxidase system

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12 December 2020

Differential toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in C57BL/6J mice congenic at the Ah Locus

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12 December 2020

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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12 December 2020

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

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12 December 2020

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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12 December 2020

Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo

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12 December 2020

Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

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12 December 2020

Enzyme induction in the cytochrome P-450 system

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12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

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12 December 2020

Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene.

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12 December 2020

Epidemiology of passive smoke: a prospective study in 589 children.

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12 December 2020

The mechanism of the warfarin-rifampin drug interaction in humans

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12 December 2020

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor

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12 December 2020

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

1 reference

12 December 2020

Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor

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12 December 2020

Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

1 reference

12 December 2020

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

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12 December 2020

The carcinogenicity of environmental tobacco smoke

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12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

1 reference

12 December 2020

Differential time-course and dose-response relationships of TCDD-induced CYP1B1, CYP1A1, and CYP1A2 proteins in rats

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12 December 2020

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

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12 December 2020

Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture

1 reference

12 December 2020

The enantioselective glucuronidation of morphine in rats and humans. Evidence for the involvement of more than one UDP-glucuronosyltransferase isoenzyme

1 reference

12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

12 December 2020

Screening for the potential of a drug candidate to cause idiosyncratic drug reactions

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12 December 2020

Warfarin metabolism and drug-drug interactions

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12 December 2020

Role of CYP2E1 in the hepatotoxicity of acetaminophen

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12 December 2020

Polymorphisms of human aryl hydrocarbon receptor (AhR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

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12 December 2020

Induction of drug metabolism: the role of nuclear receptors.

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12 December 2020

Modulation of experimental alcohol-induced liver disease by cytochrome P450 2E1 inhibitors

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12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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12 December 2020

Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254

1 reference

12 December 2020

Sequence variation and phylogenetic history of the mouse Ahr gene

1 reference

12 December 2020

Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

1 reference

12 December 2020

P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

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12 December 2020

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

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12 December 2020

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

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12 December 2020

Quinidine-Rifampin Interaction

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12 December 2020

Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes

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12 December 2020

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting P

1 reference

12 December 2020

Rifampin reduces plasma concentrations and effects of zolpidem.

1 reference

12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

1 reference

12 December 2020

A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction.

1 reference

12 December 2020

Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes.

1 reference

12 December 2020

Hepatic cytochrome P450 degradation: mechanistic diversity of the cellular sanitation brigade

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12 December 2020

Effects of smoking cessation and reduction in asthmatics

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12 December 2020

Regulation of cytochrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene

1 reference

12 December 2020

Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism.

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12 December 2020

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

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12 December 2020

Difficulties in anticoagulation management during coadministration of warfarin and rifampin

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12 December 2020

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

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12 December 2020

Rabbit pregnane X receptor is activated by rifampicin

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12 December 2020

Induction of phase I, II and III drug metabolism/transport by xenobiotics

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1 reference

12 December 2020

Consequences of rifampicin treatment on propafenone disposition in extensive and poor metabolizers of CYP2D6

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12 December 2020

Inhibition and induction of cytochrome P450 and the clinical implications

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12 December 2020

The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients

1 reference

12 December 2020

Influence of rifampicin on the expression and function of human intestinal cytochrome P450 enzymes

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12 December 2020

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

1 reference

12 December 2020

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

1 reference

12 December 2020

Calcium channel modulators of the dihydropyridine family are human pregnane X receptor activators and inducers of CYP3A, CYP2B, and CYP2C in human hepatocytes

1 reference

12 December 2020

Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics

1 reference

12 December 2020

Clearance approaches in pharmacology.

1 reference

12 December 2020

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

1 reference

12 December 2020

A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1 reference

12 December 2020

Differential expression and function of CYP2C isoforms in human intestine and liver

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12 December 2020

The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics

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12 December 2020

Induction of cytochrome P4501A1.

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12 December 2020

Glimepiride. A review of its use in the management of type 2 diabetes mellitus

1 reference

12 December 2020

Dietary effect on mixed function P450 1A2 activity assayed by estimation of caffeine metabolism in man.

1 reference

12 December 2020

Pharmacokinetic interaction between warfarin and a uricosuric agent, bucolome: application of In vitro approaches to predicting In vivo reduction of (S)-warfarin clearance

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12 December 2020

Induction of CYP2C genes in human hepatocytes in primary culture

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12 December 2020

Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers

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12 December 2020

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4

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12 December 2020

Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates

1 reference

12 December 2020

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

12 December 2020

Acute rejection and massive cyclosporine requirements in heart transplant recipients treated with rifampin

1 reference

12 December 2020

The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism

1 reference

12 December 2020

Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

1 reference

12 December 2020

Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators

1 reference

12 December 2020

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

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12 December 2020

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

1 reference

12 December 2020

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

1 reference

12 December 2020

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

12 December 2020

Microsomal generation of reactive oxygen species and their possible role in alcohol hepatotoxicity

1 reference

12 December 2020

The complex interaction between ethanol and acetaminophen

1 reference

12 December 2020

Induction and drug development

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12 December 2020

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

12 December 2020

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

1 reference

12 December 2020

Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

1 reference

12 December 2020

The in vivo turnover of rat liver microsomal epoxide hydrolase and both the apoprotein and heme moieties of specific cytochrome P-450 isozymes

1 reference

12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

12 December 2020

Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

1 reference

12 December 2020

Role of CYP1A2 in the hepatotoxicity of acetaminophen: investigations using Cyp1a2 null mice

1 reference

12 December 2020

Induction of CYP2B1 and 3A1, and associated monoxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice.

1 reference

12 December 2020

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase

1 reference

12 December 2020

Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system

1 reference

12 December 2020

The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy.

1 reference

12 December 2020

Renal allograft dysfunction associated with rifampin-tacrolimus interaction

1 reference

12 December 2020

Identification of novel splice variants of ARNT and ARNT2 in the rat.

1 reference

12 December 2020

Pharmacokinetic drug interactions of morphine, codeine, and their derivatives: theory and clinical reality, Part II.

1 reference

12 December 2020

Pharmacokinetic factors in the modern drug treatment of tuberculosis.

1 reference

12 December 2020

Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization

1 reference

12 December 2020

Inhibition and induction of human cytochrome P450 (CYP) enzymes

1 reference

12 December 2020

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

1 reference

12 December 2020

Expression of 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P4501A1 in human splenic lymphocyte cultures

1 reference

12 December 2020

Effects of rifampin on the pharmacokinetics and pharmacodynamics of glyburide and glipizide

1 reference

12 December 2020

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

1 reference

12 December 2020

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

1 reference

12 December 2020

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction

1 reference

12 December 2020

Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid

1 reference

12 December 2020

Drug interactions with tobacco smoking. An update

1 reference

12 December 2020

Interindividual variability in inhibition and induction of cytochrome P450 enzymes

1 reference

12 December 2020

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

1 reference

12 December 2020

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

1 reference

12 December 2020

Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction

1 reference

12 December 2020

Rifampicin treatment greatly increases the apparent oral clearance of quinidine

1 reference

12 December 2020

Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects

1 reference

12 December 2020

Sense and nonsense in the prediction of drug-drug interactions

1 reference

12 December 2020

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

1 reference

12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

1 reference

12 December 2020

Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents

1 reference

12 December 2020

Time response of cytochrome P450 1A2 activity on cessation of heavy smoking

1 reference

12 December 2020

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

1 reference

12 December 2020

Regulation of cyp3a gene transcription by the pregnane x receptor

1 reference

12 December 2020

Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

1 reference

12 December 2020

The effect of single does of rifampicin on the pharmacokinetics of oral nifedipine.

1 reference

12 December 2020

Effect of rifampin on the pharmacokinetics and pharmacodynamics of gliclazide

1 reference

12 December 2020

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

12 December 2020

Pharmacogenetic determinants of codeine induction by rifampin: the impact on codeine's respiratory, psychomotor and miotic effects

1 reference

12 December 2020

Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes

1 reference

12 December 2020

Influence of type of cigarette on peripheral versus central lung cancer

1 reference

12 December 2020

The inducibility and catalytic activity of cytochromes P450c (P450IA1) and P450d (P450IA2) in rat tissues

1 reference

12 December 2020

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

12 December 2020

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes

1 reference

12 December 2020

Positive regulation of the rat CYP2B2 phenobarbital response unit by the nuclear receptor hexamer half-site.nuclear factor 1 complex

1 reference

12 December 2020

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

1 reference

12 December 2020

2,3,7,8 Tetrachlorodibenzo-p-dioxin induction of cytochrome P4501A in cultured rat and human hepatocytes

1 reference

12 December 2020

Polymorphisms of human Ah receptor gene are not involved in lung cancer

1 reference

12 December 2020

Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes.

1 reference

12 December 2020

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

12 December 2020

Regulation of drug and bile salt transporters in liver and intestine

1 reference

12 December 2020

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

12 December 2020

Use of a reporter gene assay to predict and rank the potency and efficacy of CYP3A4 inducers

1 reference

12 December 2020

Rifampin drastically reduces plasma concentrations and effects of oral midazolam.

1 reference

12 December 2020

Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene

1 reference

12 December 2020

Regulation of phenobarbital induction of the cytochrome P450 2b9/10 genes in primary mouse hepatocyte culture. Involvement of calcium- and cAMP-dependent pathways

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12 December 2020

Specific and dose-dependent enzyme induction by omeprazole in human beings.

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12 December 2020

Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes

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12 December 2020

Drug interactions of HIV protease inhibitors

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12 December 2020

Dose-dependent induction of cytochrome P450 (CYP) 3A4 and activation of pregnane X receptor by topiramate

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12 December 2020

Cytochrome P-4502E1: its physiological and pathological role

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12 December 2020

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

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12 December 2020

10.1007/S11095-006-0277-7

Identifiers

DOI

1 reference

14 August 2017

1 reference