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The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.
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Europe PubMed Central
PubMed ID
12573484
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
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18 December 2019
review article
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title
The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors
(English)
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stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
author
Jean Marc Pascussi
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1
1 reference
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Europe PubMed Central
PubMed ID
12573484
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
Sabine Gerbal-Chaloin
series ordinal
2
1 reference
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Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
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18 December 2019
author name string
L Drocourt
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3
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Europe PubMed Central
PubMed ID
12573484
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
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18 December 2019
P Maurel
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4
1 reference
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Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
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18 December 2019
M J Vilarem
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5
1 reference
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Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
language of work or name
English
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publication date
1 February 2003
1 reference
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Europe PubMed Central
PubMed ID
12573484
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
volume
1619
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
page(s)
243-253
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
issue
3
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
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Cytochrome P450 and the individuality of species
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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.
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A single nucleotide polymorphism of CYP2b6 found in Japanese enhances catalytic activity by autoactivation
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7 January 2021
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The role of CYP2B6 in human xenobiotic metabolism
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Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor
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7 January 2021
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Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics
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7 January 2021
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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR
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Clinical relevance of genetic polymorphisms in the human CYP2C subfamily
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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions
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7 January 2021
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Cytochrome P-450 3A4: regulation and role in drug metabolism
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Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.
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Gene induction by Phenobarbital: an update on an old question that receives key novel answers
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7 January 2021
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Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.
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Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.
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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene
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7 January 2021
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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
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7 January 2021
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SXR, a novel steroid and xenobiotic-sensing nuclear receptor
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7 January 2021
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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
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7 January 2021
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inferred from DOI database lookup
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
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The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways
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Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.
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Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor
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A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro
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Orphan nuclear receptors: from gene to function
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Molecular mechanisms of action of steroid/thyroid receptor superfamily members
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Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors
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Transcriptional coregulators of the nuclear receptor superfamily: coactivators and corepressors.
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Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel
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Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes
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Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.
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Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif
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Characterization of DNA-binding proteins required for glucocorticoid induction of CYP3A23.
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Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7.
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Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene
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7 January 2021
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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
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7 January 2021
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Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Use of the nuclear receptor PXR to predict drug interactions
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Endogenous glucocorticoids induced by a chemical stressor (ethanol) cause apoptosis in the spleen in B6C3F1 female mice
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Steroid-induced osteoporosis
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7 January 2021
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Glucocorticoid osteoporosis--mechanisms and management
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7 January 2021
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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity
1 reference
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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
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Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated t
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enzyme induction in the cytochrome P-450 system
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenobarbital induction of cytochrome P-450 gene expression
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of a phenobarbital-responsive element (PBRE) in the 5'-flanking region of the rat CYP2B2 gene.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Estrogen activation of the nuclear orphan receptor CAR (constitutive active receptor) in induction of the mouse Cyp2b10 gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Gene regulation by vitamin D3.
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
A new analog of 1,25-(OH)2D3, 19-NOR-1,25-(OH)2D2, suppresses serum PTH and parathyroid gland growth in uremic rats without elevation of intestinal vitamin D receptor content
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
The renal function of 25-hydroxyvitamin D3-1alpha-hydroxylase
1 reference
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https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of rifampicin and isoniazid on vitamin D metabolism
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a functional glucocorticoid response element in the CYP3A1/IGC2 gene.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Circadian variation of the urinary 6beta-hydroxycortisol to cortisol ratio that would reflect hepatic CYP3A activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CYP2B2 phenobarbital response unit contains an accessory factor element and a putative glucocorticoid response element essential for conferring maximal phenobarbital responsiveness
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Glucocorticoid regulation of a phenobarbital-inducible cytochrome P-450 gene: the presence of a functional glucocorticoid response element in the 5'-flanking region of the CYP2B2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The antiglucocorticoid RU486 inhibits phenobarbital induction of the chicken CYP2H1 gene in primary hepatocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of phenobarbital on the transcriptional activity of liver
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0304-4165%2802%2900483-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0304-4165(02)00483-X
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
PubMed ID
12573484
1 reference
stated in
Europe PubMed Central
PubMed ID
12573484
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12573484%20AND%20SRC:MED&resulttype=core&format=json
retrieved
18 December 2019
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