(Q33608479)

English

Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment.

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

author name string

Andras Perl

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

publication date

1 February 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

43

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

32-47

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Biologic activity and safety of belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Trex1 prevents cell-intrinsic initiation of autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Rho GTPase-mediated pathways in mature CD4+ T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Altered B cell receptor signaling in human systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Altered B-cell signaling in lupus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Metabolic control of T cell activation and death in SLE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

CD28 costimulation is essential for human T regulatory expansion and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Hair loss and defective T- and B-cell function in mice lacking ORAI1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Oxidative stress, DNA methylation and carcinogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Critical roles of the PI3K/Akt signaling pathway in T cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Activated renal macrophages are markers of disease onset and disease remission in lupus nephritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Emerging biological therapies in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Altered signal transduction in SLE T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Systems biology in systemic lupus erythematosus: integrating genes, biology and immune function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Type I interferon in systemic lupus erythematosus and other autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B cell receptor signaling in human systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

High-dose acetylcysteine in idiopathic pulmonary fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Macroautophagy versus mitochondrial autophagy: a question of fate?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Reconstitution of the adult B cell repertoire after treatment with rituximab

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Rab conversion as a mechanism of progression from early to late endosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Immune cells and cytokines in systemic lupus erythematosus: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

T lymphocytes in systemic lupus erythematosus: an update

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B cells in human and murine systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Mitochondrial hyperpolarization: a checkpoint of T-cell life, death and autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Altered lipid raft-associated signaling and ganglioside expression in T lymphocytes from patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

T Cell Activation-Induced Mitochondrial Hyperpolarization Is Mediated by Ca2+- and Redox-Dependent Production of Nitric Oxide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The central role of dendritic cells and interferon-alpha in SLE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Molecular actions of sirolimus: sirolimus and mTor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

PI3K in lymphocyte development, differentiation and activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Role of endogenous retroviruses in autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Metabolic switches of T-cell activation and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

BAFF: a fundamental survival factor for B cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Regulation of B-cell signal transduction by adaptor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B cell receptor signaling and autoimmunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The role of adapter proteins in T cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Cutting edge: a role for B lymphocyte stimulator in systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Mitochondrial physiology and pathology; concepts of programmed death of organelles, cells and organisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Elevation of mitochondrial transmembrane potential and reactive oxygen intermediate levels are early events and occur independently from activation of caspases in Fas signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The monomeric guanosine triphosphatase rab4 controls an essential step on the pathway of receptor-mediated antigen processing in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-alpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 zeta chain of T-cell receptor complex and antigen-specific T-cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Human endogenous retroviral elements and autoimmunity: data and concepts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

TCR/CD3 complex-mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The role of nitric oxide in the pathogenesis of spontaneous murine autoimmune disease: increased nitric oxide production and nitric oxide synthase expression in MRL-lpr/lpr mice, and reduction of spontaneous glomerulonephritis and arthritis by orall

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Tumour necrosis factor-alpha in murine autoimmune 'lupus' nephritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The human T-cell leukemia virus-related endogenous sequence (HRES1) is located on chromosome 1 at q42.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Endogenous retroviruses: potential etiologic agents in autoimmunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

21 June 2018

Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Reconstitution of deficient T cell receptor zeta chain restores T cell signaling and augments T cell receptor/CD3-induced interleukin-2 production in patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Autophagy is essential for mitochondrial clearance in mature T lymphocytes

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Anti-DNA Ig peptides promote Treg cell activity in systemic lupus erythematosus patients

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Vpu-mediated degradation of CD4 reconstituted in yeast reveals mechanistic differences to cellular ER-associated protein degradation

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Increased ubiquitination and reduced expression of LCK in T lymphocytes from patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Phosphorylation abnormalities: NZB mice exhibit a B-cell signalling defect

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE).

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Endothelial nitric oxide synthase regulates T cell receptor signaling at the immunological synapse.

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Fc epsilon receptor type I gamma chain replaces the deficient T cell receptor zeta chain in T cells of patients with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

An orally bioavailable spleen tyrosine kinase inhibitor delays disease progression and prolongs survival in murine lupus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Rituximab and mycophenolate mofetil for relapsing proliferative lupus nephritis: a long-term prospective study

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Alterations in lipid raft composition and dynamics contribute to abnormal T cell responses in systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Oxidative stress is involved in the heat stress-induced downregulation of TCR zeta chain expression and TCR/CD3-mediated [Ca(2+)](i) response in human T-lymphocytes

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Glutathione Levels and Sensitivity to Apoptosis Are Regulated by Changes in Transaldolase Expression

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Autoimmune Diseases Induced by TNF-Targeted Therapies

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus

1 reference

https://api.crossref.org/works/10.3109%2F08916930903374774

21 January 2018

Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020422

30 October 2018

Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic administration of belimumab, a BLyS antagonist, decreases tissue and peripheral blood B-lymphocyte populations in cynomolgus monkeys: pharmacokinetic, pharmacodynamic, and toxicologic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous autoimmune disease in Fc(gamma)RIIB-deficient mice results from strain-specific epistasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin prolongs survival and arrests pathophysiologic changes in murine systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sublethal levels of oxidative stress stimulate transcriptional activation of c-jun and suppress IL-2 promoter activation in Jurkat T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide and mitochondrial biogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of NFAT1 in B cell self-tolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective FcgammaRIIb1 signaling contributes to enhanced calcium response in B cells from patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fas ligand induction in human NK cells is regulated by redox through a calcineurin-nuclear factors of activated T cell-dependent pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus correlate with systemic lupus erythematosus and autoreactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab improves peripheral B cell abnormalities in human systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of short-term infliximab therapy on autoantibodies in systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered lipid raft-associated proximal signaling and translocation of CD45 tyrosine phosphatase in B lymphocytes from patients with systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20001421

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3109/08916930903374774

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20001421%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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