(Q33635059)

28 July 2017

title

Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system (English)

1 reference

28 July 2017

Shreya Datta

1

1 reference

28 July 2017

Megan E Bucks

2

1 reference

28 July 2017

Dipankar Koley

3

1 reference

28 July 2017

Pei Xin Lim

4

1 reference

28 July 2017

Sergey N Savinov

5

1 reference

28 July 2017

language of work or name

English

0 references

publication date

22 June 2010

1 reference

Bioorganic & Medicinal Chemistry

28 July 2017

published in

1 reference

28 July 2017

volume

18

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28 July 2017

issue

16

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28 July 2017

page(s)

6099-6108

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Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

28 July 2017

cites work

1 reference

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21 June 2018

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p53--a Jack of all trades but master of none

21 June 2018

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Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction.

21 June 2018

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

21 June 2018

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Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

21 June 2018

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Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

21 June 2018

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Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

21 June 2018

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Molecular basis for the inhibition of p53 by Mdmx

21 June 2018

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MDM2 and MDM4: p53 regulators as targets in anticancer therapy

21 June 2018

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21 June 2018

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21 June 2018

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Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.

21 June 2018

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21 June 2018

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Hdmx modulates the outcome of p53 activation in human tumor cells

21 June 2018

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

21 June 2018

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Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.

21 June 2018

1 reference

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Engineering an affinity tag for genetically encoded cyclic peptides

21 June 2018

1 reference

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ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

21 June 2018

1 reference

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A systematic method for identifying small-molecule modulators of protein-protein interactions

21 June 2018

1 reference

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Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity

21 June 2018

1 reference

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21 June 2018

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Inhibiting the p53-MDM2 interaction: an important target for cancer therapy

21 June 2018

1 reference

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MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination

21 June 2018

1 reference

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Molecular mechanism of the interaction between MDM2 and p53.

21 June 2018

1 reference

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Converting a peptide into a drug: strategies to improve stability and bioavailability

21 June 2018

1 reference

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Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria

21 June 2018

1 reference

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Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922946

A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

21 June 2018

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Development of a binding assay for p53/HDM2 by using homogeneous time-resolved fluorescence.

21 June 2018

1 reference

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Production of cyclic peptides and proteins in vivo

21 June 2018

1 reference

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MDM2 interacts with MDMX through their RING finger domains

21 June 2018

1 reference

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Recognition of DNA by single-chain derivatives of the phage 434 repressor: high affinity binding depends on both the contacted and non-contacted base pairs

21 June 2018

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Identification of novel mdm2 binding peptides by phage display.

21 June 2018

1 reference

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 June 2018

1 reference

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Constrained peptides as binding entities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922946

Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922946

A two-hybrid system based on chimeric operator recognition for studying protein homo/heterodimerization in Escherichia coli

30 October 2018

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12 December 2020

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

12 December 2020

Miniature protein inhibitors of the p53-hDM2 interaction

1 reference

12 December 2020

Effect of restricted conformational flexibility on the permeation of model hexapeptides across Caco-2 cell monolayers

1 reference

12 December 2020

Genetic system for reversible integration of DNA constructs and lacZ gene fusions into the Escherichia coli chromosome

1 reference

12 December 2020

10.1016/J.BMC.2010.06.053

Identifiers

DOI

1 reference

release_tlulkattb5ampe23fseh5q3k7u

28 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/tlulkattb5ampe23fseh5q3k7u

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2922946

1 reference

28 July 2017

1 reference