(Q35004843)

5 August 2017

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title

p53--a Jack of all trades but master of none (English)

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5 August 2017

Melissa R Junttila

1

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5 August 2017

Gerard I Evan

series ordinal

2

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5 August 2017

language of work or name

English

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publication date

24 September 2009

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5 August 2017

published in

Nature Reviews Cancer

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5 August 2017

volume

9

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5 August 2017

issue

11

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5 August 2017

page(s)

821-829

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https://scigraph.springernature.com/pub.10.1038/nrc2728

5 August 2017

exact match

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cites work

Early diversification and complex evolutionary history of the p53 tumor suppressor gene family.

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Biochemical and functional evidence of p53 homology is inconsistent with molecular phylogenetics for distant sequences

31 March 2020

1 reference

p53 regulates maternal reproduction through LIF

31 March 2020

1 reference

Regulation of SIRT1 protein levels by nutrient availability

31 March 2020

1 reference

p53 regulates mitochondrial respiration

31 March 2020

1 reference

Regulation of autophagy by cytoplasmic p53

31 March 2020

1 reference

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

31 March 2020

1 reference

Tumor suppressor dosage regulates stem cell dynamics during aging

31 March 2020

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p53 family in development

31 March 2020

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Guardian ancestry: fly p53 and damage-inducible apoptosis

31 March 2020

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Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

31 March 2020

1 reference

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

31 March 2020

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

31 March 2020

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

31 March 2020

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

31 March 2020

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

31 March 2020

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The complexity of p53 stabilization and activation

31 March 2020

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

31 March 2020

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Timed somatic deletion of p53 in mice reveals age-associated differences in tumor progression

31 March 2020

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

31 March 2020

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

31 March 2020

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

31 March 2020

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

31 March 2020

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

31 March 2020

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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

31 March 2020

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Tumour biology: Policing of oncogene activity by p53

31 March 2020

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

31 March 2020

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Modeling the therapeutic efficacy of p53 restoration in tumors

31 March 2020

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Restoration of p53 function leads to tumour regression in vivo

31 March 2020

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

31 March 2020

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"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

31 March 2020

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INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence

31 March 2020

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Role of p14(ARF) in replicative and induced senescence of human fibroblasts

31 March 2020

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31 March 2020

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Developmental and tissue-specific regulation of mouse telomerase and telomere length

31 March 2020

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Transient expression of the Arf tumor suppressor during male germ cell and eye development in Arf-Cre reporter mice

31 March 2020

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The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development

31 March 2020

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Ink4a/Arf expression is a biomarker of aging

31 March 2020

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

31 March 2020

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Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

31 March 2020

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Polycomb CBX7 has a unifying role in cellular lifespan

31 March 2020

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Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers.

31 March 2020

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Repression of the Arf tumor suppressor by E2F3 is required for normal cell cycle kinetics

31 March 2020

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Role of the proto-oncogene Pokemon in cellular transformation and ARF repression

31 March 2020

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Regulation of the Arf/p53 tumor surveillance network by E2F.

31 March 2020

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Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor

31 March 2020

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Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

31 March 2020

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Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis.

31 March 2020

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Distinct thresholds govern Myc's biological output in vivo

31 March 2020

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Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis.

31 March 2020

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The p53 family and programmed cell death

31 March 2020

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Live or let die: the cell's response to p53

31 March 2020

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Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms

31 March 2020

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p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

31 March 2020

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Mutant p53: an oncogenic transcription factor

31 March 2020

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Induction of genetic instability by gain-of-function p53 cancer mutants

31 March 2020

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The oncogenic roles of p53 mutants in mouse models

31 March 2020

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The ARF tumor suppressor can promote the progression of some tumors.

31 March 2020

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New functional activities for the p21 family of CDK inhibitors

31 March 2020

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The common biology of cancer and ageing

31 March 2020

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Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

31 March 2020

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Resistance to viral infection of super p53 mice.

31 March 2020

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Delayed ageing through damage protection by the Arf/p53 pathway

31 March 2020

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p53 mutant mice that display early ageing-associated phenotypes

31 March 2020

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DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53.

31 March 2020

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p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

31 March 2020

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Modulation of mammalian life span by the short isoform of p53.

31 March 2020

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Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53.

31 March 2020

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Cancer and ageing: rival demons?

31 March 2020

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PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

31 March 2020

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Complicating the role of p53 in aging.

31 March 2020

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Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam

31 March 2020

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Tumor suppression and normal aging in mice with constitutively high p53 activity

31 March 2020

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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

31 March 2020

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Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development

31 March 2020

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

31 March 2020

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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

31 March 2020

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

31 March 2020

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

31 March 2020

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Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

31 March 2020

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Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death

31 March 2020

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Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

31 March 2020

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Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development

31 March 2020

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Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo.

31 March 2020

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p63 protects the female germ line during meiotic arrest

31 March 2020

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The fossil record and the early evolution of the Metazoa

31 March 2020

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TP53 and mutations in human cancer

31 March 2020

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12 December 2020

mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development

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12 December 2020

Tumor spectrum in ARF-deficient mice.

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12 December 2020

p53-independent functions of MDM2.

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12 December 2020

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF.

1 reference

12 December 2020

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum

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12 December 2020

Identifiers

DOI

10.1038/NRC2728

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5 August 2017

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