(Q37068656)

18 August 2017

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title

Induction of genetic instability by gain-of-function p53 cancer mutants (English)

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18 August 2017

Y Xu

1

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18 August 2017

language of work or name

English

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publication date

28 January 2008

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18 August 2017

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18 August 2017

volume

27

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18 August 2017

issue

25

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18 August 2017

page(s)

3501-3507

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1211023

18 August 2017

exact match

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cites work

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Atm-deficient mice: a paradigm of ataxia telangiectasia

21 January 2018

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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The signals and pathways activating cellular senescence

21 January 2018

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Oncogene-induced senescence as an initial barrier in lymphoma development

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The Mre11 complex is required for ATM activation and the G2/M checkpoint

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Gain of function mutations in p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Definition of a consensus binding site for p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The p53 proto-oncogene can act as a suppressor of transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Drug resistance in cancer: a perspective

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Structure-function-rescue: the diverse nature of common p53 cancer mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Oncogenic forms of p53 inhibit p53-regulated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

21 January 2018

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

On the road to cancer: aneuploidy and the mitotic checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Mutant p53 protein expression interferes with p53-independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53 suppresses the self-renewal of adult neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The impact of translocations and gene fusions on cancer causation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Tumor-derived p53 mutant C174Y is a gain-of-function mutant which activates the fos promoter and enhances colony formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Mammalian p53 can function as a transcription factor in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

ATM: genome stability, neuronal development, and cancer cross paths

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

The p53 family in differentiation and tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Mutant p53: an oncogenic transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

A global map of p53 transcription-factor binding sites in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Transcription regulation by mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

A new role for p53 in maintaining genetic stability in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Dual roles of ATM in the cellular response to radiation and in cell growth control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Involvement of p53 and p21 in cellular defects and tumorigenesis in Atm-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Complicating the complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Chromatin structural elements and chromosomal translocations in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Microarray Analysis of p53-Mediated Transcription: Mutli-Thousand Piece Puzzle or Invitation to Collective Thinking?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Wild-type p53 activates transcription in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

The Thousand Doors that Lead to Death: p53-Dependent Repression and Apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211023

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1211023

1 reference

18 August 2017

1 reference