(Q33658642)

28 July 2017

title

Computational models of HIV-1 resistance to gene therapy elucidate therapy design principles (English)

1 reference

28 July 2017

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4

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author name string

Sharon Aviran

series ordinal

1

1 reference

28 July 2017

Priya S Shah

series ordinal

2

1 reference

28 July 2017

David V Schaffer

series ordinal

3

1 reference

28 July 2017

publication date

12 August 2010

1 reference

PLOS Computational Biology

28 July 2017

published in

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28 July 2017

volume

6

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28 July 2017

issue

8

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Creative Commons CC0 License

28 July 2017

copyright license

start time

12 August 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

0 references

cites work

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Silencing of HIV-1 with RNA interference: a multiple shRNA approach

21 June 2018

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Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir

21 June 2018

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Can gene delivery close the door to HIV-1 entry after escape?

21 June 2018

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21 June 2018

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Removal of arginine 332 allows human TRIM5alpha to bind human immunodeficiency virus capsids and to restrict infection

21 June 2018

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Gene-based immunotherapy for human immunodeficiency virus infection and acquired immunodeficiency syndrome

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Modeling and estimation of replication fitness of human immunodeficiency virus type 1 in vitro experiments by using a growth competition assay

21 June 2018

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Primary human T lymphocytes engineered with a codon-optimized IL-15 gene resist cytokine withdrawal-induced apoptosis and persist long-term in the absence of exogenous cytokine

21 June 2018

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Survival of the fittest: in vivo selection and stem cell gene therapy

21 June 2018

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Evolution of mutational robustness in an RNA virus

21 June 2018

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21 June 2018

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21 June 2018

1 reference

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CXCR4 and CCR5 shRNA transgenic CD34+ cell derived macrophages are functionally normal and resist HIV-1 infection

21 June 2018

1 reference

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T Lymphocytes transduced with a lentiviral vector expressing F12-Vif are protected from HIV-1 infection in an APOBEC3G-independent manner.

21 June 2018

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Impact of gene-modified T cells on HIV infection dynamics

21 June 2018

1 reference

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Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT.

21 June 2018

1 reference

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Computational design of antiviral RNA interference strategies that resist human immunodeficiency virus escape.

21 June 2018

1 reference

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Evidence for Positive Epistasis in HIV-1

21 June 2018

1 reference

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T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120.

21 June 2018

1 reference

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Antisense-mediated inhibition of human immunodeficiency virus (HIV) replication by use of an HIV type 1-based vector results in severely attenuated mutants incapable of developing resistance

21 June 2018

1 reference

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HIV-1 dynamics in vivo: implications for therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition

21 June 2018

1 reference

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Competitive fitness of nevirapine-resistant human immunodeficiency virus type 1 mutants

21 June 2018

1 reference

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Inhibition of human immunodeficiency virus type 1 entry in cells expressing gp41-derived peptides

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

MicroRNAs modulate hematopoietic lineage differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Barriers to nonviral gene delivery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Thymic regeneration: teaching an old immune system new tricks

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Maintaining the norm: T-cell homeostasis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Modelling viral and immune system dynamics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Redundancy, antiredundancy, and the robustness of genomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Transition between stochastic evolution and deterministic evolution in the presence of selection: general theory and application to virology.

21 June 2018

1 reference

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Estimating relative fitness in viral competition experiments.

21 June 2018

1 reference

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Production of resistant HIV mutants during antiretroviral therapy

21 June 2018

1 reference

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Factors influencing T-cell turnover in HIV-1-seropositive patients

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Gene therapy of T helper cells in HIV infection: Mathematical model of the criteria for clinical effect

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Decay characteristics of HIV-1-infected compartments during combination therapy

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Viral dynamics in human immunodeficiency virus type 1 infection

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2920833

Transfer of Autologous Gene-modified T Cells in HIV-infected Patients with Advanced Immunodeficiency and Drug-resistant Virus

21 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000883

Preferential survival of CD4+ T lymphocytes engineered with anti-human immunodeficiency virus (HIV) genes in HIV-infected individuals

21 January 2018

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Long-term inhibition of HIV-1 infection in primary hematopoietic cells by lentiviral vector delivery of a triple combination of anti-HIV shRNA, anti-CCR5 ribozyme, and a nucleolar-localizing TAR decoy

21 January 2018

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Towards a general function describing T cell proliferation.

21 January 2018

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Naive T cells are maintained by thymic output in early ages but by proliferation without phenotypic change after age twenty.

21 January 2018

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Evidence for increased T cell turnover and decreased thymic output in HIV infection

21 January 2018

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Recombination in HIV and the evolution of drug resistance: for better or for worse?

21 January 2018

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Hematopoietic stem cell transduction and amplification in large animal models

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000883

Comprehensive assessment and mathematical modeling of T cell population dynamics and homeostasis

21 January 2018

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Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans

21 January 2018

1 reference

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Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization

21 January 2018

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12 December 2020

Effect of deleterious mutation-accumulation on the fitness of RNA bacteriophage MS2

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12 December 2020

Building an HIV-proof immune system

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12 December 2020

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12 December 2020

Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.1000883

Identifiers

DOI

1 reference

journals/ploscb/AviranSSA10

28 July 2017

DBLP publication ID

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

28 July 2017

1 reference