(Q33665370)

24799681

28 July 2017

title

Hypochlorite-induced structural modifications enhance the chaperone activity of human α2-macroglobulin (English)

1 reference

28 July 2017

0 references

1

1 reference

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2 June 2020

Mark R. Wilson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

2

Janet R Kumita

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

author name string

Richard W Mifsud

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Cherrie A Gooden

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

Christopher M Dobson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

language of work or name

English

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publication date

5 May 2014

1 reference

24799681

Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

volume

111

1 reference

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2 June 2020

issue

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

page(s)

E2081-90

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

Molecular chaperone functions in protein folding and proteostasis

2 June 2020

cites work

1 reference

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Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

21 June 2018

1 reference

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Extracellular chaperones and proteostasis.

21 June 2018

1 reference

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Widespread regulation of translation by elongation pausing in heat shock

21 June 2018

1 reference

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Fibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen.

21 June 2018

1 reference

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Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Acute phase proteins are major clients for the chaperone action of α₂-macroglobulin in human plasma

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.

21 June 2018

1 reference

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Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins

21 June 2018

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The crystal structure of human α2-macroglobulin reveals a unique molecular cage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Human Protein-disulfide Isomerase Is a Redox-regulated Chaperone Activated by Oxidation of Domain a′

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

21 June 2018

1 reference

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Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

The immune system in atherosclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Identification of human plasma proteins as major clients for the extracellular chaperone clusterin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Amyloid formation by the pro-inflammatory S100A8/A9 proteins in the ageing prostate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Bleach activates a redox-regulated chaperone by oxidative protein unfolding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Immunological features of alpha-synuclein in Parkinson's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Redox regulation in the extracellular environment

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Protein misfolding, functional amyloid, and human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Myeloperoxidase: friend and foe

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Protein s-glutathionylation in retinal pigment epithelium converts heat shock protein 70 to an active chaperone.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Hypochlorite-induced oxidation of amino acids, peptides and proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Characterization of non-covalent oligomers of proteins treated with hypochlorous acid

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Identification of oxidized plasma proteins in Alzheimer's disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Oxidation of methionine in proteins: roles in antioxidant defense and cellular regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Alpha2-macroglobulin associates with beta-amyloid peptide and prevents fibril formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Immunological evidence for hypochlorite-modified proteins in human kidney

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Cells in stress: transcriptional activation of heat shock genes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Deposits of alpha 2M in the rheumatoid synovial membrane

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Generation of free radical intermediates from foreign compounds by neutrophil-derived oxidants

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Tissue destruction by neutrophils

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Rheumatoid arthritis. Pathophysiology and implications for therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

The oxidant hypochlorite (OCl−), a product of the myeloperoxidase system, degrades articular cartilage proteoglycan aggregate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Temperature dependence of the kinetics of the urea-induced dissociation of human plasma alpha 2-macroglobulin into half-molecules. A minimum rate at 15 degrees C indicates hydrophobic interaction between the subunits

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Alpha 2-macroglobulin, a multifunctional binding protein with targeting characteristics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Soluble proteins in the human atherosclerotic plaque. With spectral reference to immunoglobulins, C3-complement component, alpha 1-antitrypsin and alpha 2-macroglobulin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Heat-induced fragmentation of human alpha 2-macroglobulin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

21 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Inhibition of beta2-microglobulin amyloid fibril formation by alpha2-macroglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

The subunits of alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein, native and transformed alpha2-macroglobulin and interleukin 6 in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Effects of oxidized fibrinogen on the functions of blood cells, blood clotting, and rheology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Neurodegenerative diseases and oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Neutrophil granulocytes uniquely express, among human blood cells, high levels of Methionine-sulfoxide-reductase enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Aggregates of denatured proteins stimulate nitric oxide and superoxide production in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

The Acid Ionization Constant of HOCl from 5 to 35°

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1403379111

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Generation of IgG aggregates by the myeloperoxidase-hydrogen peroxide system

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4034205

Oxidized low-density lipoprotein induces macrophage respiratory burst via its protein moiety: A novel pathway in atherogenesis?

30 October 2018

1 reference

12 December 2020

Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha 2-macroglobulin

1 reference

12 December 2020

The acute phase protein haptoglobin is a mammalian extracellular chaperone with an action similar to clusterin

1 reference

12 December 2020

Protease activation of alpha2-macroglobulin modulates a chaperone-like action with broad specificity

1 reference

12 December 2020

Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers

1 reference

12 December 2020

Alpha-crystallin can act as a chaperone under conditions of oxidative stress

1 reference

12 December 2020

alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species

1 reference

12 December 2020

Myeloperoxidase and oxidative stress in rheumatoid arthritis

1 reference

12 December 2020

The contact zones in human alpha2-macroglobulin--functional domains important for the regulation of the trapping mechanism

1 reference

12 December 2020

The binding of receptor-recognized alpha2-macroglobulin to the low density lipoprotein receptor-related protein and the alpha2M signaling receptor is decoupled by oxidation

1 reference

12 December 2020

Bait region involvement in the dimer-dimer interface of human alpha 2-macroglobulin and in mediating gross conformational change. Evidence from cysteine variants that form interdimer disulfides

1 reference

12 December 2020

Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure

1 reference

12 December 2020

Selective modification of apoB-100 in the oxidation of low density lipoproteins by myeloperoxidase in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1403379111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json

2 June 2020

24799681

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799681%20AND%20SRC:MED&resulttype=core&format=json