(Q33671206)

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Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor

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13 March 2020

Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor (English)

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13 March 2020

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Roberta Imperatore

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13 March 2020

Enrico D'Aniello

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13 March 2020

Fabiana Piscitelli

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13 March 2020

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F Guida

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13 March 2020

L Luongo

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S Boccella

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M E Giordano

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R Romano

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G Bellini

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I Manzo

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A Furiano

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F A Iannotti

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23 March 2017

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13 March 2020

Scientific Reports

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13 March 2020

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23 March 2017

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https://scigraph.springernature.com/pub.10.1038/s41598-017-00342-1

0 references

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Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections

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Palmitoylethanolamide in CNS health and disease

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Glia and mast cells as targets for palmitoylethanolamide, an anti-inflammatory and neuroprotective lipid mediator

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Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice.

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28 July 2018

Palmitoylethanolamide protects dentate gyrus granule cells via peroxisome proliferator-activated receptor-α

1 reference

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Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia

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Current challenges in glia-pain biology

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Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.

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28 July 2018

Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation

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28 July 2018

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

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28 July 2018

Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain

1 reference

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28 July 2018

Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of palmitoylethanolamide

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28 July 2018

The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors

1 reference

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28 July 2018

Neuroimmune interactions and pain: focus on glial-modulating targets

1 reference

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28 July 2018

CB2 receptor-mediated migration of immune cells: it can go either way

1 reference

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Cannabinoid receptors and endocannabinoids: evidence for new players.

1 reference

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28 July 2018

Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation

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28 July 2018

Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals.

1 reference

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28 July 2018

Cannabinoid receptors in microglia of the central nervous system: immune functional relevance

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28 July 2018

The search for the palmitoylethanolamide receptor.

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The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro

1 reference

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28 July 2018

Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility.

1 reference

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28 July 2018

Nonpsychotropic cannabinoid receptors regulate microglial cell migration.

1 reference

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28 July 2018

Microglial activation by purines and pyrimidines

1 reference

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28 July 2018

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

1 reference

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A role for the endogenous cannabinoid system in the peripheral control of pain initiation

1 reference

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28 July 2018

Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells

1 reference

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Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.

1 reference

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Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide

1 reference

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Prophylactic efficacy of N-2-hydroxyethyl palmitamide (impulsin) in acute respiratory tract infections.

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The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations

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Palmitoylethanolamide reduces pain-related behaviors and restores glutamatergic synapses homeostasis in the medial prefrontal cortex of neuropathic mice.

1 reference

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1 reference

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1 reference

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30 October 2018

Palmitoylethanolamide reduces formalin-induced neuropathic-like behaviour through spinal glial/microglial phenotypical changes in mice

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30 October 2018

Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 and Streptococcus pneumoniae R6 by microglial cells

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Pathological and protective roles of glia in chronic pain

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30 October 2018

Activated microglia contribute to the maintenance of chronic pain after spinal cord injury.

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30 October 2018

A novel neuroimmune mechanism in cannabinoid-mediated attenuation of nerve growth factor-induced hyperalgesia

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30 October 2018

Clinical and histological evaluation of an analogue of palmitoylethanolamide, PLR 120 (comicronized Palmidrol INN) in cats with eosinophilic granuloma and eosinophilic plaque: a pilot study.

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30 October 2018

Endocannabinoid 2-arachidonyl glycerol is a full agonist through human type 2 cannabinoid receptor: antagonism by anandamide.

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30 October 2018

Control of pain initiation by endogenous cannabinoids.

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30 October 2018

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

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30 October 2018

5'-Chloro-5'-deoxy-(±)-ENBA, a potent and selective adenosine A(1) receptor agonist, alleviates neuropathic pain in mice through functional glial and microglial changes without affecting motor or cardiovascular functions

1 reference

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12 December 2020

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10.1038/S41598-017-00342-1

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Europe PubMed Central

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13 March 2020

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13 March 2020

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13 March 2020

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