(Q33698048)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24746821%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity (English)

1 reference

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14 March 2020

16

1 reference

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14 March 2020

Mikko Turunen

1

1 reference

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14 March 2020

Salla Keskitalo

3

1 reference

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14 March 2020

Netta Mäkinen

7

1 reference

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14 March 2020

Kimmo Palin

9

1 reference

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14 March 2020

Anna Vähärautio

11

1 reference

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14 March 2020

Markku Varjosalo

17

1 reference

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14 March 2020

author name string

Jason M Spaeth

2

1 reference

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14 March 2020

Min Ju Park

4

1 reference

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14 March 2020

Teemu Kivioja

5

1 reference

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14 March 2020

Alison D Clark

6

1 reference

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14 March 2020

Fangjian Gao

8

1 reference

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14 March 2020

Helka Nurkkala

10

1 reference

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14 March 2020

Mervi Aavikko

12

1 reference

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14 March 2020

Kati Kämpjärvi

13

1 reference

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14 March 2020

Pia Vahteristo

14

1 reference

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14 March 2020

Chongwoo A Kim

15

1 reference

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14 March 2020

Jussi Taipale

18

1 reference

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14 March 2020

Thomas G Boyer

19

1 reference

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14 March 2020

publication date

18 April 2014

1 reference

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14 March 2020

1 reference

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14 March 2020

volume

7

1 reference

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14 March 2020

issue

3

1 reference

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14 March 2020

page(s)

654-660

1 reference

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describes a project that uses

14 March 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4041330/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

The protein interaction landscape of the human CMGC kinase group

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

21 June 2018

Cancer genome landscapes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

A structural perspective on Mediator function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator and human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Function and regulation of the Mediator complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

The human Mediator complex: a versatile, genome-wide regulator of transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

CDK8 is a positive regulator of transcriptional elongation within the serum response network

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

An integrated workflow for charting the human interaction proteome: insights into the PP2A system

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator modulates Gli3-dependent Sonic hedgehog signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator and the mechanism of transcriptional activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

TFIIH is negatively regulated by cdk8-containing mediator complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Characterization of uterine leiomyomas by whole-genome sequencing.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Mediator is a transducer of Wnt/beta-catenin signaling.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

Structure of the mediator subunit cyclin C and its implications for CDK8 function

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4041330

10.1016/J.CELREP.2014.03.047

30 October 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24746821%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24746821%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

24746821

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24746821%20AND%20SRC:MED&resulttype=core&format=json