(Q33763540)

29 July 2017

title

Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma (English)

1 reference

intrahepatic cholangiocarcinoma

29 July 2017

0 references

dasatinib monohydrate

1 reference

based on heuristic

inferred from title

1 reference

1 reference

28

Nabeel Bardeesy

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Leah J Damon

Leah J Damon

11

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James T. Webber

James T Webber

10

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Benjamin P Kleinstiver

Benjamin P Kleinstiver

3

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Lei Shi

Lei Shi

7

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Yusuke Mizukami

Yusuke Mizukami

21

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Ultan McDermott

Ultan McDermott

14

0 references

J. Keith Joung

25

J Keith Joung

1 reference

29 July 2017

13

Patricia Greninger

1 reference

29 July 2017

Supriya K Saha

1

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29 July 2017

John D Gordan

2

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29 July 2017

Phuong Vu

4

1 reference

29 July 2017

Mortada S Najem

5

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29 July 2017

Jia-Chi Yeo

6

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29 July 2017

Yasutaka Kato

8

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29 July 2017

Rebecca S Levin

9

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29 July 2017

Regina K Egan

12

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29 July 2017

Mathew J Garnett

15

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29 July 2017

Roger L Jenkins

16

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29 July 2017

Kimberly M Rieger-Christ

17

1 reference

29 July 2017

Travis B Sullivan

18

1 reference

29 July 2017

Aram F Hezel

19

1 reference

29 July 2017

Andrew S Liss

20

1 reference

29 July 2017

Lipika Goyal

22

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29 July 2017

Cristina R Ferrone

23

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29 July 2017

Andrew X Zhu

24

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29 July 2017

Kevan M Shokat

26

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29 July 2017

Cyril H Benes

27

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29 July 2017

Nabeel Bardeesy

28

1 reference

29 July 2017

publication date

26 May 2016

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29 July 2017

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29 July 2017

volume

6

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29 July 2017

issue

7

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29 July 2017

page(s)

727-739

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Forty-Year Trends in Cholangiocarcinoma Incidence in the U.S.: Intrahepatic Disease on the Rise

29 July 2017

cites work

1 reference

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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.

14 July 2018

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Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation

14 July 2018

1 reference

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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

14 July 2018

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Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma

14 July 2018

1 reference

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Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

14 July 2018

1 reference

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14 July 2018

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14 July 2018

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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

14 July 2018

1 reference

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14 July 2018

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14 July 2018

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Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.

14 July 2018

1 reference

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14 July 2018

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14 July 2018

1 reference

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New routes to targeted therapy of intrahepatic cholangiocarcinomas revealed by next-generation sequencing

14 July 2018

1 reference

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Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

14 July 2018

1 reference

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Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

14 July 2018

1 reference

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Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities

14 July 2018

1 reference

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High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

14 July 2018

1 reference

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Molecular profiling of cholangiocarcinoma shows potential for targeted therapy treatment decisions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Systematic identification of genomic markers of drug sensitivity in cancer cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

IDH mutation impairs histone demethylation and results in a block to cell differentiation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Comprehensive analysis of kinase inhibitor selectivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer

14 July 2018

1 reference

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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

14 July 2018

1 reference

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Principles of cancer therapy: oncogene and non-oncogene addiction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Transient potent BCR-ABL inhibition is sufficient to commit chronic myeloid leukemia cells irreversibly to apoptosis

14 July 2018

1 reference

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Src and focal adhesion kinase as therapeutic targets in cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

A quantitative analysis of kinase inhibitor selectivity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

14 July 2018

1 reference

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Strategies to overcome resistance to targeted protein kinase inhibitors

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

IDH mutations in liver cell plasticity and biliary cancer

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the Sarah Cannon research institute

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Kras(G12D) and p53 mutation cause primary intrahepatic cholangiocarcinoma

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response o

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5458737

A molecular gate which controls unnatural ATP analogue recognition by the tyrosine kinase v-Src

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27231123

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/2159-8290.CD-15-1442

1 reference

29 July 2017

1 reference

29 July 2017

1 reference