(Q33765746)

29 July 2017

LRRK2 levels in immune cells are increased in Parkinson's disease (English)

1 reference

29 July 2017

1 reference

11

M G Tansey

1 reference

29 July 2017

D A Cook

1

1 reference

29 July 2017

G T Kannarkat

2

1 reference

29 July 2017

A F Cintron

3

1 reference

29 July 2017

Laura M Butkovich

4

1 reference

29 July 2017

Kyle B Fraser

5

1 reference

29 July 2017

J Chang

6

1 reference

29 July 2017

N Grigoryan

7

1 reference

29 July 2017

S A Factor

8

1 reference

29 July 2017

Andrew B West

9

1 reference

29 July 2017

J M Boss

10

1 reference

29 July 2017

28 March 2017

1 reference

29 July 2017

NPJ Parkinson's disease

1 reference

29 July 2017

3

1 reference

29 July 2017

11

1 reference

Creative Commons Attribution 4.0 International

29 July 2017

start time

28 March 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41531-017-0010-8

0 references

cites work

mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Inhibitor treatment of peripheral mononuclear cells from Parkinson's disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Heterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implications

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

LRRK2 and neuroinflammation: partners in crime in Parkinson's disease?

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

LRRK2 inhibition attenuates microglial inflammatory responses

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Regulation of LRRK2 expression points to a functional role in human monocyte maturation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

LRRK2 is involved in the IFN-gamma response and host response to pathogens

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Receptor-interacting protein (RIP) kinase family.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Smoking duration, intensity, and risk of Parkinson disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Genomewide association study of leprosy

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The LRRK2 G2019S mutation as the cause of Parkinson's disease in Ashkenazi Jews

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Debris clearance by microglia: an essential link between degeneration and regeneration.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Induction of the CTLA-4 gene in human lymphocytes is dependent on NFAT binding the proximal promoter

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Inflammation as a causative factor in the aetiology of Parkinson's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The CD14+ CD16+ blood monocytes: their role in infection and inflammation

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

LRRK2 in Parkinson's disease: protein domains and functional insights

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Genetics of Parkinson's disease: LRRK2 on the rise

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

The RIP kinases: crucial integrators of cellular stress

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

A meta-analysis of coffee drinking, cigarette smoking, and the risk of Parkinson's disease

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Antigen presentation and T cell stimulation by dendritic cells

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Lessons from the bare lymphocyte syndrome: molecular mechanisms regulating MHC class II expression.

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Brefeldin A: the advantage of being uncompetitive

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

22 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5459798

Clinical features of LRRK2-associated Parkinson's disease in central Norway

22 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

LRRK2 deficiency impacts ceramide metabolism in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

The role of LRRK2 in the regulation of monocyte adhesion to endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

Commentary: Progressive inflammation as a contributing factor to early development of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

https://api.crossref.org/works/10.1038%2FS41531-017-0010-8

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41531-017-0010-8

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference