(Q38111307)

29 August 2017

The neurobiology of LRRK2 and its role in the pathogenesis of Parkinson's disease (English)

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29 August 2017

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Hardy J Rideout

1

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PubMed ID

23729298

29 August 2017

Leonidas Stefanis

series ordinal

2

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29 August 2017

1 June 2013

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29 August 2017

Neurochemical Research

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29 August 2017

39

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29 August 2017

3

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29 August 2017

576-592

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https://scigraph.springernature.com/pub.10.1007/s11064-013-1073-5

29 August 2017

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cites work

The GTPase function of LRRK2.

1 reference

12 December 2020

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

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12 December 2020

alpha-Synuclein shares physical and functional homology with 14-3-3 proteins

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12 December 2020

Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2.

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12 December 2020

Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S

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12 December 2020

The Roco protein family: a functional perspective

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12 December 2020

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

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12 December 2020

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

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12 December 2020

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

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12 December 2020

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

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12 December 2020

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.

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12 December 2020

Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers

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12 December 2020

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

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12 December 2020

LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis

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12 December 2020

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

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12 December 2020

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

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12 December 2020

Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations

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12 December 2020

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

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12 December 2020

LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP.

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12 December 2020

LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models

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12 December 2020

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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12 December 2020

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

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12 December 2020

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

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12 December 2020

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

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12 December 2020

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

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12 December 2020

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies

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12 December 2020

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

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12 December 2020

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

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12 December 2020

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

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12 December 2020

Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

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12 December 2020

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

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12 December 2020

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

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12 December 2020

Number and brightness analysis of LRRK2 oligomerization in live cells

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12 December 2020

Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.

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12 December 2020

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

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12 December 2020

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

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12 December 2020

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

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12 December 2020

Genome-wide association study reveals genetic risk underlying Parkinson's disease

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12 December 2020

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

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12 December 2020

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

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12 December 2020

Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease

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12 December 2020

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

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12 December 2020

Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells

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12 December 2020

Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-β prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.

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12 December 2020

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation

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12 December 2020

The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

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12 December 2020

GTPase activity plays a key role in the pathobiology of LRRK2.

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12 December 2020

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

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12 December 2020

Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.

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12 December 2020

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

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12 December 2020

Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions

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12 December 2020

Role of mendelian genes in "sporadic" Parkinson's disease

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12 December 2020

LRRK2 regulates synaptic vesicle endocytosis

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12 December 2020

Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

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12 December 2020

RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis.

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12 December 2020

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

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12 December 2020

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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12 December 2020

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity.

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12 December 2020

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice

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12 December 2020

RICK/RIP2 Mediates Innate Immune Responses Induced through Nod1 and Nod2 but Not TLRs

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12 December 2020

Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations

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12 December 2020

Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations.

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12 December 2020

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

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12 December 2020

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

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12 December 2020

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

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12 December 2020

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

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12 December 2020

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

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12 December 2020

Genetic animal models for evaluating the role of autophagy in etiopathogenesis of Parkinson disease

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12 December 2020

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

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12 December 2020

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

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12 December 2020

The Parkinson disease gene LRRK2: evolutionary and structural insights

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12 December 2020

Complex I: inhibitors, inhibition and neurodegeneration

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12 December 2020

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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12 December 2020

Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation.

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12 December 2020

Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway

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12 December 2020

The RIP kinases: crucial integrators of cellular stress

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12 December 2020

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

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12 December 2020

α-Synuclein aggregation and transmission are enhanced by leucine-rich repeat kinase 2 in human neuroblastoma SH-SY5Y cells

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12 December 2020

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain

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12 December 2020

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

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12 December 2020

Mechanism of endophilin N-BAR domain-mediated membrane curvature

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12 December 2020

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

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12 December 2020

Death-effector filaments: novel cytoplasmic structures that recruit caspases and trigger apoptosis

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12 December 2020

LRRK2 inhibition attenuates microglial inflammatory responses

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12 December 2020

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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12 December 2020

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

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12 December 2020

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

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12 December 2020

A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11.2-q13.1.

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12 December 2020

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

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12 December 2020

Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis

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12 December 2020

Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake

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12 December 2020

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

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12 December 2020

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

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12 December 2020

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

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12 December 2020

LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

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12 December 2020

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

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12 December 2020

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

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12 December 2020

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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12 December 2020

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

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12 December 2020

Kinase activity of mutant LRRK2 mediates neuronal toxicity

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12 December 2020

High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain

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12 December 2020

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

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12 December 2020

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

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12 December 2020

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

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12 December 2020

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

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12 December 2020

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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12 December 2020

JNK regulates FoxO-dependent autophagy in neurons

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12 December 2020

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

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12 December 2020

Down-regulation of FoxO-dependent c-FLIP expression mediates TRAIL-induced apoptosis in activated hepatic stellate cells

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12 December 2020

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

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12 December 2020

A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

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12 December 2020

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

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12 December 2020

LRRK2 Parkinson disease mutations enhance its microtubule association.

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12 December 2020

Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis

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12 December 2020

Pathological roles of α-synuclein in neurological disorders

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12 December 2020

Unexpected lack of hypersensitivity in LRRK2 knock-out mice to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).

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12 December 2020

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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12 December 2020

Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2.

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12 December 2020

Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease.

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12 December 2020

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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12 December 2020

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

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12 December 2020

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

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12 December 2020

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

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12 December 2020

Caspase recruitment domain (CARD)-dependent cytoplasmic filaments mediate bcl10-induced NF-kappaB activation

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12 December 2020

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

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12 December 2020

LRRK2 I2020T mutation is associated with tau pathology.

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12 December 2020

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

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12 December 2020

Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain.

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12 December 2020

LRRK2 expression linked to dopamine-innervated areas

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12 December 2020

A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis

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12 December 2020

Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group

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12 December 2020

Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications

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12 December 2020

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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12 December 2020

LRRK2 is involved in the IFN-gamma response and host response to pathogens

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12 December 2020

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

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12 December 2020

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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12 December 2020

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

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12 December 2020

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice.

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12 December 2020

10.1007/S11064-013-1073-5

Identifiers

DOI

1 reference

PubMed ID

23729298

Dimensions Publication ID

29 August 2017

0 references

1 reference

PubMed ID

23729298