(Q38044433)

27 August 2017

The GTPase function of LRRK2. (English)

1 reference

27 August 2017

Jean-Marc Taymans

1

1 reference

27 August 2017

1 October 2012

1 reference

Biochemical Society Transactions

27 August 2017

1 reference

27 August 2017

40

1 reference

27 August 2017

5

1 reference

27 August 2017

1063-1069

1 reference

Roc, a Ras/GTPase domain in complex proteins

27 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The Roco protein family: a functional perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Founder mutation p.R1441C in the leucine-rich repeat kinase 2 gene in Belgian Parkinson's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Molecular pathogenesis of Parkinson disease: insights from genetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

LRRK2 gene variation and its contribution to Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The R1441C mutation alters the folding properties of the ROC domain of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Integrating signals from RTKs to ERK/MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Quantitative analysis of the complex between p21ras and the Ras-binding domain of the human Raf-1 protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Identification of the autophosphorylation sites of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Structure-function relationships of the G domain, a canonical switch motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

GEFs: structural basis for their activation of small GTP-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Identification of a novel guanine nucleotide exchange factor for the Rho GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The ARF1 GTPase-activating protein: zinc finger motif and Golgi complex localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

It takes two to tango: regulation of G proteins by dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Kinases as targets for Parkinson's disease: from genetics to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Kinase signaling pathways as potential targets in the treatment of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

A clinic-based study of the LRRK2 gene in Parkinson disease yields new mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120133

21 January 2018

Identifiers

DOI

10.1042/BST20120133

1 reference

27 August 2017

1 reference

PubMed ID

22988866