(Q38000327)

26 August 2017

title

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies (English)

1 reference

26 August 2017

1 reference

1 reference

Kostas Vekrellis

1

1 reference

26 August 2017

Leonidas Stefanis

series ordinal

2

1 reference

26 August 2017

language of work or name

English

0 references

publication date

1 April 2012

1 reference

Expert Opinion on Therapeutic Targets

26 August 2017

published in

1 reference

26 August 2017

volume

16

1 reference

26 August 2017

issue

4

1 reference

26 August 2017

page(s)

421-432

1 reference

Neurobiology of alpha-synuclein

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Molecular pathogenesis of Parkinson disease: insights from genetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

alpha-Synucleinopathy models and human neuropathology: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Detection of elevated levels of soluble alpha-synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

In vivo demonstration that alpha-synuclein oligomers are toxic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Pharmacological prevention of Parkinson disease in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Inducible over-expression of wild type alpha-synuclein in human neuronal cells leads to caspase-dependent non-apoptotic death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

A soluble α-synuclein construct forms a dynamic tetramer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Controlling the mass action of alpha-synuclein in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Age-associated increases of alpha-synuclein in monkeys and humans are associated with nigrostriatal dopamine depletion: Is this the target for Parkinson's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Absence of alpha-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

A novel pathway for transcriptional regulation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

α-Synuclein expression is induced by depolarization and cyclic AMP in enteric neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Methylation regulates alpha-synuclein expression and is decreased in Parkinson's disease patients' brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Repression of alpha-synuclein expression and toxicity by microRNA-7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Chaperone-mediated autophagy markers in Parkinson disease brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Proteasomal inhibition-induced inclusion formation and death in cortical neurons require transcription and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Phosphorylation of synucleins by members of the Polo-like kinase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Exosomes: the Trojan horses of neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Synuclein activates microglia in a model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Nitrated alpha-synuclein and microglial neuroregulatory activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

A novel, high-efficiency cellular model of fibrillar alpha-synuclein inclusions and the examination of mutations that inhibit amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Assessment of α-synuclein secretion in mouse and human brain parenchyma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Antibodies against alpha-synuclein reduce oligomerization in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Isolation of a human single chain antibody fragment against oligomeric alpha-synuclein that inhibits aggregation and prevents alpha-synuclein-induced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Detecting morphologically distinct oligomeric forms of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Suppression of Huntington's disease pathology in Drosophila by human single-chain Fv antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Research in motion: the enigma of Parkinson's disease pathology spread

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

Collaborative Analysis of α-Synuclein Gene Promoter Variability and Parkinson Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.674111

10.1517/14728222.2012.674111

21 January 2018

Identifiers

DOI

1 reference

release_s2n5bjgwfrddjnztubcfpt5uze

26 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/s2n5bjgwfrddjnztubcfpt5uze

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference