(Q33785755)

29 July 2017

title

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release (English)

1 reference

29 July 2017

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1

Suman Jayadev

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Gwenn A Garden

object named as

Gwenn A Garden

9

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author name string

Amanda Case

2

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29 July 2017

Alison J Eastman

3

1 reference

29 July 2017

Huy Nguyen

4

1 reference

29 July 2017

Julia Pollak

5

1 reference

29 July 2017

Jesse C Wiley

6

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29 July 2017

Thomas Möller

7

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29 July 2017

Richard S Morrison

8

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29 July 2017

language of work or name

English

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publication date

29 December 2010

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29 July 2017

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29 July 2017

volume

5

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29 July 2017

issue

12

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29 July 2017

page(s)

e15743

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Creative Commons Attribution 4.0 International

29 July 2017

copyright license

start time

29 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity

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Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.

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IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice

4 July 2018

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Neuroinflammation in Parkinson's disease

4 July 2018

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Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice

4 July 2018

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Systemic inflammation and disease progression in Alzheimer disease

4 July 2018

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Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury

4 July 2018

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Heterogeneity of microglial activation in the innate immune response in the brain

4 July 2018

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Microglial low-density lipoprotein receptor-related protein 1 modulates c-Jun N-terminal kinase activation

4 July 2018

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4 July 2018

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The canonical Notch signaling pathway: unfolding the activation mechanism

4 July 2018

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Microglial physiology: unique stimuli, specialized responses

4 July 2018

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The role of neuroimmunomodulation in Alzheimer's disease.

4 July 2018

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Presenilin: RIP and beyond

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes

4 July 2018

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Gamma-secretase limits the inflammatory response through the processing of LRP1

4 July 2018

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Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.

4 July 2018

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Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways

4 July 2018

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Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis

4 July 2018

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4 July 2018

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Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation

4 July 2018

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Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition

4 July 2018

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

4 July 2018

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Defective signal transduction in B lymphocytes lacking presenilin proteins

4 July 2018

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Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease.

4 July 2018

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

4 July 2018

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Notch signaling modulates the activation of microglial cells

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice

4 July 2018

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The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

4 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Notch-1 up-regulation and signaling following macrophage activation modulates gene expression patterns known to affect antigen-presenting capacity and cytotoxic activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

The microglial "activation" continuum: from innate to adaptive responses

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Toll-like receptor signalling

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Intrathecal inflammation precedes development of Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Alternative activation of macrophages

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Inflammation, apoptosis, and Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Does IFNgamma play a role in neurodegeneration?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Inflammation and Alzheimer's disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Cloning and characterization of the presenilin-2 gene promoter

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Enhancement of immunoreactivity for NF-kappa B in human cerebral infarctions.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012089

Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice.

4 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Lentiviral transduction of microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Notch signaling is activated by TLR stimulation and regulates macrophage functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0015743

Lentivirus Vectors Encoding Both Central Polypurine Tract and Posttranscriptional Regulatory Element Provide Enhanced Transduction and Transgene Expression

21 January 2018

1 reference

12 December 2020

Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide

1 reference

12 December 2020

Constitutive and cytokine-regulated expression of presenilin-1 and presenilin-2 genes in human neural cell lines

1 reference

12 December 2020

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015743

Identifiers

DOI

1 reference

release_nd3u2fv4xjcrnl3aszkpmviepa

29 July 2017

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1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nd3u2fv4xjcrnl3aszkpmviepa

24 November 2022

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PMC publication ID

3012089

1 reference

29 July 2017

1 reference