(Q33791025)

29 July 2017

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title

Mitochondrial integrity: preservation through Akt/Pim-1 kinase signaling in the cardiomyocyte (English)

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29 July 2017

Mark A Sussman

1

1 reference

29 July 2017

language of work or name

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1 August 2009

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Expert Review of Cardiovascular Therapy

29 July 2017

published in

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29 July 2017

volume

7

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29 July 2017

issue

8

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29 July 2017

page(s)

929-938

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Nuclear and mitochondrial signalling Akts in cardiomyocytes

29 July 2017

cites work

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation

4 July 2018

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Preconditioning-mimetics bradykinin and DADLE activate PI3-kinase through divergent pathways

4 July 2018

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Preconditioning: the mitochondrial connection

4 July 2018

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Different fates of mitochondria: alternative ways for degradation?

4 July 2018

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

4 July 2018

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Constitutively activated FLT3 phosphorylates BAD partially through pim-1.

4 July 2018

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Leptin, the obesity-associated hormone, exhibits direct cardioprotective effects

4 July 2018

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The modulation of inter-organelle cross-talk to control apoptosis

4 July 2018

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Mitochondrial function in cardiomyocytes: target for cardioprotection

4 July 2018

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Signalling via the reperfusion injury signalling kinase (RISK) pathway links closure of the mitochondrial permeability transition pore to cardioprotection

4 July 2018

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Structure and substrate specificity of the Pim-1 kinase

4 July 2018

1 reference

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The survival kinases Akt and Pim as potential pharmacological targets

4 July 2018

1 reference

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PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury

4 July 2018

1 reference

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The reperfusion injury salvage kinase pathway: a common target for both ischemic preconditioning and postconditioning.

4 July 2018

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Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

4 July 2018

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Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

4 July 2018

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The serine/threonine kinase Pim-1

4 July 2018

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

4 July 2018

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Kinase signaling cascades in the mitochondrion: a matter of life or death.

4 July 2018

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Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter

4 July 2018

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Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

4 July 2018

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On the InterAktion between hexokinase and the mitochondrion.

4 July 2018

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STATs as critical mediators of signal transduction and transcription: lessons learned from STAT5.

4 July 2018

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Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore

4 July 2018

1 reference

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New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway

4 July 2018

1 reference

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Rapid accumulation of Akt in mitochondria following phosphatidylinositol 3-kinase activation

4 July 2018

1 reference

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Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases

4 July 2018

1 reference

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Mitochondrial function: the heart of myocardial preservation

4 July 2018

1 reference

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

4 July 2018

1 reference

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The pims and outs of survival signaling: role for the Pim-2 protein kinase in the suppression of apoptosis by cytokines

4 July 2018

1 reference

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

4 July 2018

1 reference

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Adrenomedullin gene delivery attenuates myocardial infarction and apoptosis after ischemia and reperfusion

4 July 2018

1 reference

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Prolactin-regulated pim-1 transcription: identification of critical promoter elements and Akt signaling

4 July 2018

1 reference

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Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.

4 July 2018

1 reference

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

4 July 2018

1 reference

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Akt/protein kinase B promotes organ growth in transgenic mice

4 July 2018

1 reference

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

4 July 2018

1 reference

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Glycoprotein 130 regulates cardiac myocyte survival in doxorubicin-induced apoptosis through phosphatidylinositol 3-kinase/Akt phosphorylation and Bcl-xL/caspase-3 interaction

4 July 2018

1 reference

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Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066730

Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066730

The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway

4 July 2018

1 reference

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

4 July 2018

1 reference

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Ubiquitous expression and cell cycle regulation of the protein kinase PIM-1.

4 July 2018

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Differentiation-Associated Expression of the Proto-Oncogene pim-1 in Cultured Human Keratinocytes

4 July 2018

1 reference

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Localization of the human pim oncogene (PIM) to a region of chromosome 6 involved in translocations in acute leukemias

4 July 2018

1 reference

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Characterization of the human PIM-1 gene: a putative proto-oncogene coding for a tissue specific member of the protein kinase family

4 July 2018

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Oncogene expression in murine splenic T cells and in murine T-cell neoplasms

4 July 2018

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Recombinant human pim-1 protein exhibits serine/threonine kinase activity

4 July 2018

1 reference

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RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis

4 July 2018

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Transgenic expression of Bcl-2 modulates energy metabolism, prevents cytosolic acidification during ischemia, and reduces ischemia/reperfusion injury

21 January 2018

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Dual signaling via protein kinase C and phosphatidylinositol 3'-kinase/Akt contributes to bradykinin B2 receptor-induced cardioprotection in guinea pig hearts

21 January 2018

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Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria

21 January 2018

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Bradykinin prevents reperfusion injury by targeting mitochondrial permeability transition pore through glycogen synthase kinase 3beta

21 January 2018

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Mapping preconditioning's signaling pathways: an engineering approach.

21 January 2018

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Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning

21 January 2018

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IL-6 induces PI 3-kinase and nitric oxide-dependent protection and preserves mitochondrial function in cardiomyocytes

21 January 2018

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Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway.

21 January 2018

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Limitation of infarct size by erythropoietin is associated with translocation of Akt to the mitochondria after reperfusion

21 January 2018

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Overexpression of glutaredoxin-2 reduces myocardial cell death by preventing both apoptosis and necrosis

21 January 2018

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Localizing extracellular signal-regulated kinase (ERK) in pharmacological preconditioning's trigger pathway

21 January 2018

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Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes

21 January 2018

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Fluorescent indicators for Akt/protein kinase B and dynamics of Akt activity visualized in living cells

21 January 2018

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Contribution of the PI 3-kinase/Akt survival pathway toward osmotic preconditioning

21 January 2018

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

21 January 2018

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Mitochondrial hexokinases: guardians of the mitochondria

21 January 2018

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Akt mediates mitochondrial protection in cardiomyocytes through phosphorylation of mitochondrial hexokinase-II.

21 January 2018

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Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes

21 January 2018

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Myc-driven murine prostate cancer shares molecular features with human prostate tumors

21 January 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

21 January 2018

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Myocardial Akt activation and gender: increased nuclear activity in females versus males

21 January 2018

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Pim-1 regulates cardiomyocyte survival downstream of Akt.

21 January 2018

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Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart

21 January 2018

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Effects of chronic Akt activation on glucose uptake in the heart

21 January 2018

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Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

21 January 2018

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IL-5 and granulocyte-macrophage colony-stimulating factor activate STAT3 and STAT5 and promote Pim-1 and cyclin D3 protein expression in human eosinophils

21 January 2018

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Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.

30 October 2018

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Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells

30 October 2018

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12 December 2020

Mitophagy: growing in intricacy

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12 December 2020

[Protein kinases in mitochondria]

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12 December 2020

Akt signaling and growth of the heart

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12 December 2020

Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning

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12 December 2020

[Mitochondrial permeability transition pore opening inhibition by ecdysterone in heart mitochondria of aging rats]

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12 December 2020

Mitochondrial DNA mutations activate programmed cell survival in the mouse heart

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12 December 2020

Pharmacological postconditioning with the phytoestrogen genistein

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12 December 2020

Essential role of lipid raft in ischemic preconditioning

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12 December 2020

The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action

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12 December 2020

Regulation of IGF-I receptor signaling in diabetic cardiac muscle: dysregulation of cytosolic and mitochondria HSP60

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12 December 2020

Role of pim-1 in smooth muscle cell proliferation

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12 December 2020

Identifiers

DOI

10.1586/ERC.09.48

1 reference

29 July 2017

1 reference

29 July 2017

1 reference