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Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.
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Europe PubMed Central
PMCID
5468793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
title
Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function
(English)
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Europe PubMed Central
PMCID
5468793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
author
Naoe T Nihira
series ordinal
1
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Europe PubMed Central
PMCID
5468793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
Kouhei Shimizu
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3
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Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
Brian J North
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4
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5468793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
Daming Gao
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6
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5468793
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
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2 April 2020
Hiroyuki Inuzuka
series ordinal
7
1 reference
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Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
Wenyi Wei
series ordinal
8
1 reference
stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
author name string
Kohei Ogura
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2
1 reference
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Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
Jinfang Zhang
series ordinal
5
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5468793
reference URL
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2 April 2020
publication date
14 February 2017
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Europe PubMed Central
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5468793
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retrieved
2 April 2020
published in
Science Signaling
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stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
volume
10
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Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
issue
466
1 reference
stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
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Autoactivation of the MDM2 E3 ligase by intramolecular interaction
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4 July 2018
Acetyltransferase p300 regulates NBS1-mediated DNA damage response
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4 July 2018
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
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4 July 2018
Lysine acetylation targets protein complexes and co-regulates major cellular functions
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4 July 2018
Acetylation of non-histone proteins modulates cellular signalling at multiple levels
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4 July 2018
A complex barcode underlies the heterogeneous response of p53 to stress
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4 July 2018
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
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4 July 2018
Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
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4 July 2018
p53 ubiquitination: Mdm2 and beyond
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4 July 2018
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
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4 July 2018
Stat3 dimerization regulated by reversible acetylation of a single lysine residue
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4 July 2018
A new effector pathway links ATM kinase with the DNA damage response
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4 July 2018
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
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4 July 2018
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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4 July 2018
Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
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4 July 2018
Acetylation of the adenovirus-transforming protein E1A determines nuclear localization by disrupting association with importin-alpha
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4 July 2018
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
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4 July 2018
PUMA, a novel proapoptotic gene, is induced by p53
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4 July 2018
Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma
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4 July 2018
Regulation of p53 function
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PubMed Central
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4 July 2018
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
Surfing the p53 network
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
1 reference
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4 July 2018
Identification of a cryptic nucleolar-localization signal in MDM2
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4 July 2018
p300/MDM2 complexes participate in MDM2-mediated p53 degradation
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
DNA damage activates p53 through a phosphorylation-acetylation cascade
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
The MDM2 gene amplification database
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
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4 July 2018
Nuclear protein import
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
retrieved
4 July 2018
MDM2-regulated degradation of HIPK2 prevents p53Ser46 phosphorylation and DNA damage-induced apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
retrieved
30 October 2018
Homeodomain-interacting protein kinase 2 is the ionizing radiation-activated p53 serine 46 kinase and is regulated by ATM.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
retrieved
30 October 2018
The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5468793
retrieved
30 October 2018
Identifiers
DOI
10.1126/SCISIGNAL.AAI8026
1 reference
stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PMCID
5468793
1 reference
stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
PubMed ID
28196907
1 reference
stated in
Europe PubMed Central
PMCID
5468793
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28196907%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 April 2020
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