(Q33849709)

29 July 2017

title

Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity (English)

1 reference

29 July 2017

Paul A Wender

1

1 reference

29 July 2017

Jeremy L Baryza

2

1 reference

29 July 2017

Stacey E Brenner

3

1 reference

29 July 2017

Brian A DeChristopher

4

1 reference

29 July 2017

Brian A Loy

5

1 reference

29 July 2017

Adam J Schrier

6

1 reference

29 July 2017

Vishal A Verma

7

1 reference

29 July 2017

publication date

17 March 2011

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29 July 2017

number of pages

6

1 reference

Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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29 July 2017

volume

108

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29 July 2017

issue

17

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29 July 2017

page(s)

6721-6726

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Total synthesis of bryostatin 1

29 July 2017

cites work

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The design, synthesis, and evaluation of C7 diversified bryostatin analogs reveals a hot spot for PKC affinity

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Simplified analogs of bryostatin with anticancer activity display greater potency for translocation of PKCdelta-GFP.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritina

5 July 2018

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Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli

5 July 2018

1 reference

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Total Synthesis of Bryostatin 3

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084132

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5 July 2018

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Bax:Bcl-2 ratio modulation by bryostatin 1 and novel antitubulin agents is important for susceptibility to drug induced apoptosis in the human early pre-B acute lymphoblastic leukemia cell line, Reh.

5 July 2018

1 reference

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5 July 2018

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5 July 2018

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PKC-independent modulation of multidrug resistance in cells with mutant (V185) but not wild-type (G185) P-glycoprotein by bryostatin 1.

5 July 2018

1 reference

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The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts

5 July 2018

1 reference

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Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084132

Analysis of the phorbol ester pharmacophore on protein kinase C as a guide to the rational design of new classes of analogs

5 July 2018

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Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

5 July 2018

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Function-oriented synthesis of simplified caprazamycins: discovery of oxazolidine-containing uridine derivatives as antibacterial agents against drug-resistant bacteria

21 January 2018

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Isolation and structure of bryostatin 1

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Modulation of resistance to ara-C by bryostatin in fresh blast cells from patients with AML.

21 January 2018

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A multi-center phase II study of sequential paclitaxel and bryostatin-1 (NSC 339555) in patients with untreated, advanced gastric or gastroesophageal junction adenocarcinoma.

21 January 2018

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Prolonging microtubule dysruption enhances the immunogenicity of chronic lymphocytic leukaemia cells

21 January 2018

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Synthesis of bryostatin 7

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Total Synthesis of Bryostatin 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Substitution on the A-ring confers to bryopyran analogues the unique biological activity characteristic of bryostatins and distinct from that of the phorbol esters

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Targeting the protein kinase C family: are we there yet?

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Design, Synthesis, and Biological Evaluation of a Potent, PKC Selective, B-Ring Analog of Bryostatin

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Directed reduction of .beta.-hydroxy ketones employing tetramethylammonium triacetoxyborohydride

21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.1015270108

Desmethyl Macrolide Analogues to Address Antibiotic Resistance: Total Synthesis and Biological Evaluation of 4,8,10-Tridesmethyl Telithromycin.

21 January 2018

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Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies.

29 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084132

Antineoplastic Components of Marine Animals

29 October 2018

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Potent cytotoxins produced by a microbial symbiont protect host larvae from predation

21 January 2018

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12 December 2020

Effect of CD40 ligand and other immunomodulators on Pneumocystis carinii infection in rat model

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12 December 2020

Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

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12 December 2020

The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices

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12 December 2020

Domain structure and phosphorylation of protein kinase C

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1015270108

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference