(Q33866783)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28674429%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

title

Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway (English)

1 reference

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24 March 2020

7

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24 March 2020

author name string

Jian-Guo Ren

1

1 reference

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24 March 2020

Pankaj Seth

2

1 reference

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24 March 2020

Huihui Ye

3

1 reference

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24 March 2020

Kun Guo

4

1 reference

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24 March 2020

Jun-Ichi Hanai

5

1 reference

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24 March 2020

Zaheed Husain

6

1 reference

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24 March 2020

language of work or name

English

0 references

publication date

3 July 2017

1 reference

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24 March 2020

1 reference

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24 March 2020

volume

7

1 reference

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24 March 2020

issue

1

1 reference

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24 March 2020

page(s)

4537

1 reference

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Creative Commons Attribution 4.0 International

24 March 2020

copyright license

start time

3 July 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-04626-4

0 references

cites work

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Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

5 July 2018

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5 July 2018

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3-bromopyruvate and sodium citrate target glycolysis, suppress survivin, and induce mitochondrial-mediated apoptosis in gastric cancer cells and inhibit gastric orthotopic transplantation tumor growth

5 July 2018

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Citrate synthase expression affects tumor phenotype and drug resistance in human ovarian carcinoma

5 July 2018

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5 July 2018

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Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

5 July 2018

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MUC1: a multifaceted oncoprotein with a key role in cancer progression

5 July 2018

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Inhibition of Mcl-1 expression by citrate enhances the effect of Bcl-xL inhibitors on human ovarian carcinoma cells

5 July 2018

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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.

5 July 2018

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ATP citrate lyase knockdown impacts cancer stem cells in vitro

5 July 2018

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Spermine and citrate as metabolic biomarkers for assessing prostate cancer aggressiveness

5 July 2018

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PTEN-regulated AKT/FoxO3a/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells.

5 July 2018

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A model for cancer-suppressive inflammation

5 July 2018

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Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.

5 July 2018

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Citrate kills tumor cells through activation of apical caspases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Understanding the central role of citrate in the metabolism of cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Citrate induces apoptotic cell death: a promising way to treat gastric carcinoma?

5 July 2018

1 reference

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High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy

5 July 2018

1 reference

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Induction of erythroid differentiation in human erythroleukemia cells by depletion of malic enzyme 2

5 July 2018

1 reference

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Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?

5 July 2018

1 reference

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Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)

5 July 2018

1 reference

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Effect of citrate on malignant pleural mesothelioma cells: a synergistic effect with cisplatin.

5 July 2018

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

5 July 2018

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Insulin, insulin-like growth factors and neoplasia

5 July 2018

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Targeting insulin and insulin-like growth factor signalling in oncology

5 July 2018

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PKR in innate immunity, cancer, and viral oncolysis

5 July 2018

1 reference

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MUC1: a target molecule for cancer therapy

5 July 2018

1 reference

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IQGAP1 modulates activation of B-Raf

5 July 2018

1 reference

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Citrate concentrations in human seminal fluid and expressed prostatic fluid determined via 1H nuclear magnetic resonance spectroscopy outperform prostate specific antigen in prostate cancer detection

5 July 2018

1 reference

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

5 July 2018

1 reference

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Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Validating cancer drug targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Akt stimulates aerobic glycolysis in cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Correlation of the effects of citric acid cycle metabolites on succinate oxidation by rat liver mitochondria and submitochondrial particles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target.

5 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

The mitochondrial citrate carrier: a new player in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Activation of the integrated stress response during T helper cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Targeting isocitrate dehydrogenase (IDH) in cancer.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Effect of sodium citrate ingestion on oxygen debt & exercise endurance during supramaximal exercise

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

The physiological and ventilatory responses to repeated 60 s sprints following sodium citrate ingestion

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5495754

Citrate as an Intermediary in the Inhibition of Phosphofructokinase in Rat Heart Muscle by Fatty Acids, Ketone Bodies, Pyruvate, Diabetes and Starvation

29 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

Hypothesis proved...citric acid (citrate) does improve cancer: a case of a patient suffering from medullary thyroid cancer

21 January 2018

2 references

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

7 January 2021

12 December 2020

Clinical report: a patient with primary peritoneal mesothelioma that has improved after taking citric acid orally

2 references

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

7 January 2021

12 December 2020

A critical role for citrate metabolism in LPS signalling

2 references

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

7 January 2021

12 December 2020

Clinical significance of IGF1R gene expression in patients with Stage II/III gastric cancer who receive curative surgery and adjuvant chemotherapy with S-1

2 references

https://api.crossref.org/works/10.1038%2FS41598-017-04626-4

7 January 2021

12 December 2020

Regulation of pyruvate dehydrogenase in muscle. Inhibition by citrate

1 reference

12 December 2020

10.1038/S41598-017-04626-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28674429%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

24 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28674429%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

PubMed publication ID

28674429

1 reference