(Q33871220)

29 July 2017

title

Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways (English)

1 reference

29 July 2017

Suzzette M Arnal

1

1 reference

29 July 2017

Abigail J Holub

series ordinal

2

1 reference

29 July 2017

Sandra S Salus

series ordinal

3

1 reference

29 July 2017

David B Roth

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

4 February 2010

1 reference

29 July 2017

published in

Nucleic Acids Research

1 reference

29 July 2017

volume

38

1 reference

29 July 2017

issue

9

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29 July 2017

page(s)

2944-2954

1 reference

describes a project that uses

29 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2875030/fullTextXML

inferred from PubMed Central ID database lookup

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5 July 2018

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Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

5 July 2018

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5 July 2018

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5 July 2018

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

5 July 2018

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5 July 2018

1 reference

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5 July 2018

1 reference

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5 July 2018

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5 July 2018

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5 July 2018

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RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

5 July 2018

1 reference

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5 July 2018

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DNA sequence and structure requirements for cleavage of V(D)J recombination signal sequences

5 July 2018

1 reference

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Distinct DNA sequence and structure requirements for the two steps of V(D)J recombination signal cleavage

5 July 2018

1 reference

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5 July 2018

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Essential residues in V(D)J recombination signals

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

1 reference

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The V(D)J recombination activating gene, RAG-1.

5 July 2018

1 reference

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5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

RAG-1-deficient mice have no mature B and T lymphocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Amino acid residues in Rag1 crucial for DNA hairpin formation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Alternative end-joining in follicular lymphomas' t(14;18) translocation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

The homeodomain region of Rag-1 reveals the parallel mechanisms of bacterial and V(D)J recombination

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2875030

V(D)J recombination: a functional definition of the joining signals

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20139091

12 December 2020

inferred from PubMed ID database lookup

V(D)J recombination in mouse thymocytes: Double-strand breaks near T cell receptor δ rearrangement signals

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20139091

12 December 2020

inferred from PubMed ID database lookup

Rag mutations reveal robust alternative end joining

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20139091

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1093/NAR/GKP1252

1 reference

29 July 2017

1 reference

29 July 2017

1 reference