(Q33883491)

29 July 2017

title

Discovery of potent and selective inhibitors of Trypanosoma brucei ornithine decarboxylase (English)

1 reference

29 July 2017

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ornithine decarboxylase

1 reference

6 February 2019

4

Margaret A Phillips

1 reference

29 July 2017

Anang A Shelat

3

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Jeongmi Lee

object named as

Jeongmi Lee

series ordinal

2

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R. Kiplin Guy

series ordinal

5

object named as

R Kiplin Guy

1 reference

29 July 2017

David C Smithson

1

1 reference

29 July 2017

language of work or name

English

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publication date

10 March 2010

1 reference

Journal of Biological Chemistry

29 July 2017

published in

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29 July 2017

volume

285

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29 July 2017

issue

22

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29 July 2017

page(s)

16771-16781

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Optimization of a non-radioactive high-throughput assay for decarboxylase enzymes.

29 July 2017

cites work

1 reference

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Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

28 July 2018

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RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis

28 July 2018

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Regulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomes

28 July 2018

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Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial

28 July 2018

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Dual detection approach to a more accurate measure of relative purity in high-throughput characterization of compound collections

28 July 2018

1 reference

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Phylogenetic diversity and the structural basis of substrate specificity in the beta/alpha-barrel fold basic amino acid decarboxylases

28 July 2018

1 reference

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The interdependence between screening methods and screening libraries.

28 July 2018

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Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents

28 July 2018

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Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog

28 July 2018

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Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential.

28 July 2018

1 reference

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Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bond

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Potential use of alexidine dihydrochloride as an apoptosis-promoting anticancer agent

28 July 2018

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Accumulation and intracellular distribution of antitrypanosomal diamidine compounds DB75 and DB820 in African trypanosomes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

3D QSAR on a library of heterocyclic diamidine derivatives with antiparasitic activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

A perspective of polyamine metabolism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Polyamine-dependent gene expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Regulation of cellular polyamines by antizyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Altering the reaction specificity of eukaryotic ornithine decarboxylase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Expression and function of surface proteins in Trypanosoma brucei

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

The properties of known drugs. 1. Molecular frameworks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Formation of functional cross-species heterodimers of ornithine decarboxylase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Acidic residues important for substrate binding and cofactor reactivity in eukaryotic ornithine decarboxylase identified by alanine scanning mutagenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Rapid and efficient site-specific mutagenesis without phenotypic selection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Phase I trial and pharmacokinetic study of intravenous and oral alpha-difluoromethylornithine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Cloning and sequencing of the ornithine decarboxylase gene from Trypanosoma brucei. Implications for enzyme turnover and selective difluoromethylornithine inhibition.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Trypanosome ornithine decarboxylase is stable because it lacks sequences found in the carboxyl terminus of the mouse enzyme which target the latter for intracellular degradation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Intestinal ornithine decarboxylase: half-life and regulation by putrescine

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

Human African trypanosomiasis: pharmacological re-engagement with a neglected disease.

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

Quantitation of polyamines in hypothalamus and pituitary of female and male developing rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

In vitro antifungal activities of inhibitors of phospholipases from the fungal pathogen Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

The ornithine decarboxylase gene of Trypanosoma brucei: Evidence for horizontal gene transfer from a vertebrate source

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

Strategic Pooling of Compounds for High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

Innate lack of susceptibility of Ugandan Trypanosoma brucei rhodesiense to DL-alpha-difluoromethylornithine (DFMO).

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878083

In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei

29 October 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.081588

Equilibrium between active and inactive forms of rat liver ornithine decarboxylase mediated by L-ornithine and salts

21 January 2018

1 reference

12 December 2020

A simple assay for detection of small-molecule redox activity

1 reference

12 December 2020

Bioavailability study of oral liquid and tablet forms of alpha-difluoromethylornithine

1 reference

12 December 2020

Inhibitors of polyamine biosynthesis. 1. Alpha-methyl-(plus or minus)-ornithine, an inhibitor of ornithine decarboxylase

1 reference

12 December 2020

Decarboxylation of ornithine and lysine in rat tissues

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M109.081588

1 reference

29 July 2017

1 reference

29 July 2017

1 reference