(Q33888491)

24831005

29 July 2017

title

Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor (English)

1 reference

29 July 2017

1

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3 June 2020

Krzysztof Jóźwiak

2

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3 June 2020

Anita Plazinska

9

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3 June 2020

Michel Bernier

12

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3 June 2020

author name string

Lawrence Toll

3

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3 June 2020

Mary J Tanga

4

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3 June 2020

Joseph A Kozocas

5

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3 June 2020

Lucita Jimenez

6

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3 June 2020

Ying Huang

7

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3 June 2020

Ying Song

8

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3 June 2020

Karolina Pajak

10

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3 June 2020

Rajib K Paul

11

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3 June 2020

Irving W Wainer

13

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3 June 2020

Rui-Ping Xiao

14

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3 June 2020

language of work or name

English

0 references

publication date

15 May 2014

1 reference

24831005

Journal of Biological Chemistry

29 July 2017

published in

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3 June 2020

volume

289

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3 June 2020

issue

28

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3 June 2020

page(s)

19351-19363

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

3 June 2020

cites work

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The role of ligands on the equilibria between functional states of a G protein-coupled receptor

28 July 2018

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Detection of G protein-selective G protein-coupled receptor (GPCR) conformations in live cells

28 July 2018

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The dynamic process of β(2)-adrenergic receptor activation

28 July 2018

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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

28 July 2018

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Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations

28 July 2018

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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR.

28 July 2018

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Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX.

28 July 2018

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Multiple ligand-specific conformations of the β2-adrenergic receptor

28 July 2018

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RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling

28 July 2018

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Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery

28 July 2018

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Ligand-directed signalling at beta-adrenoceptors

28 July 2018

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Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists

28 July 2018

1 reference

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Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes

28 July 2018

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Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes

28 July 2018

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Beta-arrestin-biased ligands at seven-transmembrane receptors

28 July 2018

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GPCR functional selectivity has therapeutic impact

28 July 2018

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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors

28 July 2018

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Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol

28 July 2018

1 reference

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

28 July 2018

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Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies

28 July 2018

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beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

28 July 2018

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Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

28 July 2018

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Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

28 July 2018

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beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf

28 July 2018

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Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor

28 July 2018

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Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists

28 July 2018

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G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

28 July 2018

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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

28 July 2018

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28 July 2018

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Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors

28 July 2018

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Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities

28 July 2018

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Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts

21 January 2018

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Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor.

21 January 2018

1 reference

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Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.

21 January 2018

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Gi-biased β2AR signaling links GRK2 upregulation to heart failure

21 January 2018

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Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.

21 January 2018

1 reference

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Molecular interactions between fenoterol stereoisomers and derivatives and the β₂-adrenergic receptor binding site studied by docking and molecular dynamics simulations

21 January 2018

1 reference

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Differential phosphorylation and dephosphorylation of beta2-adrenoceptor sites Ser262 and Ser355,356.

21 January 2018

1 reference

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Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.

21 January 2018

1 reference

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Pathway and mechanism of drug binding to G-protein-coupled receptors.

21 January 2018

1 reference

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Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

21 January 2018

1 reference

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Structural insights into adrenergic receptor function and pharmacology

21 January 2018

1 reference

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Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor

21 January 2018

1 reference

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Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes

29 October 2018

1 reference

12 December 2020

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

12 December 2020

Missing links: mechanisms of protean agonism

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12 December 2020

Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology

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12 December 2020

Identifiers

DOI

10.1074/JBC.M114.558882

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24831005%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24831005%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

24831005

1 reference