(Q33896110)

29 July 2017

title

High fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism (English)

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29 July 2017

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Lisa Longato

1

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29 July 2017

Ming Tong

series ordinal

2

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29 July 2017

Jack R Wands

series ordinal

3

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29 July 2017

Suzanne M de la Monte

series ordinal

4

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29 July 2017

publication date

16 December 2011

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29 July 2017

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29 July 2017

volume

42

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29 July 2017

issue

4

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29 July 2017

page(s)

412-427

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Ceramide-Mediated Insulin Resistance and Impairment of Cognitive-Motor Functions

29 July 2017

cites work

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5 July 2018

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Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Oxidative stress and covalent modification of protein with bioactive aldehydes

5 July 2018

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5 July 2018

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Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1.

5 July 2018

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Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.

5 July 2018

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5 July 2018

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Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment

5 July 2018

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Lipid mediators of insulin resistance

5 July 2018

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Non-alcoholic steatohepatitis and cancer

5 July 2018

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

5 July 2018

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Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

5 July 2018

1 reference

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Free fatty acids and insulin resistance

5 July 2018

1 reference

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The role of cytokines in non-alcoholic steatohepatitis. A review

5 July 2018

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Global challenges in liver disease

5 July 2018

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A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury.

5 July 2018

1 reference

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Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

5 July 2018

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The epidemiology of nonalcoholic fatty liver disease in adults

5 July 2018

1 reference

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Nonalcoholic fatty liver disease: from steatosis to cirrhosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Ceramides in insulin resistance and lipotoxicity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it.

5 July 2018

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Inhibition of glycogen synthesis by increased lipid availability is associated with subcellular redistribution of glycogen synthase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

The natural history of nonalcoholic fatty liver disease: a population-based cohort study

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Lipid microdomains and insulin resistance: is there a connection?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Molecular mediators of hepatic steatosis and liver injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Nitric oxide, oxidants, and protein tyrosine nitration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Ceramide synthesis and metabolism as a target for cancer therapy.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Intracellular signal transduction pathways activated by ceramide and its metabolites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Nonalcoholic fatty liver disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Nile Red binding to HepG2 cells: an improved assay for in vitro studies of hepatosteatosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Ceramide in apoptosis signaling: relationship with oxidative stress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

The contradictions of the insulin-like growth factor 1 receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Sphingomyelinases in cell regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Elevated protein tyrosine phosphatase activity and increased membrane viscosity are associated with impaired activation of the insulin receptor kinase in old rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Alterations in hepatocyte insulin receptors in rats fed a choline-deficient diet.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis-acting DNA sequences

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

Insulin-stimulated hexose transport and glucose oxidation in rat adipocytes is inhibited by sphingosine at a step after insulin binding.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo. Studies with insulin, exercise, muscle denervation, and vasopressin.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096625

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Hepatic triacylglycerol accumulation and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

A lipidomic analysis of nonalcoholic fatty liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Clinicopathological significance of oxidative cellular damage in non-alcoholic fatty liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1872-034X.2011.00934.X

In vitro characterization of anti-glucosylceramide rabbit antisera

21 January 2018

1 reference

12 December 2020

Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice

1 reference

12 December 2020

Key role for ceramides in mediating insulin resistance in human muscle cells

1 reference

12 December 2020

High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei

1 reference

12 December 2020

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes

1 reference

12 December 2020

10.1111/J.1872-034X.2011.00934.X

Identifiers

DOI

1 reference

29 July 2017

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29 July 2017

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