(Q33903286)

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Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease

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Europe PubMed Central

PubMed publication ID

29 July 2017

Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

vector-borne disease

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Parkinson's disease

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Christof von Kalle

5

object named as

Christof von Kalle

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Ngoc B Lu-Nguyen

object named as

Ngoc B Lu-Nguyen

1

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Manfred Schmidt

6

object named as

Manfred Schmidt

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Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Martin Broadstock

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Maximilian G Schliesser

3

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Europe PubMed Central

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29 July 2017

Cynthia C Bartholomae

4

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Europe PubMed Central

PubMed publication ID

29 July 2017

Rafael J Yáñez-Muñoz

7

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Europe PubMed Central

PubMed publication ID

29 July 2017

publication date

15 April 2014

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Europe PubMed Central

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29 July 2017

Human Gene Therapy

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Europe PubMed Central

PubMed publication ID

29 July 2017

25

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Europe PubMed Central

PubMed publication ID

29 July 2017

7

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Europe PubMed Central

PubMed publication ID

29 July 2017

631-641

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Europe PubMed Central

PubMed publication ID

29 July 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4098822/fullTextXML

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Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

1 reference

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5 July 2018

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Efficient gene expression from integration-deficient lentiviral vectors in the spinal cord

1 reference

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5 July 2018

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk

1 reference

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5 July 2018

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites

1 reference

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5 July 2018

Retroviral integrations in gene therapy trials

1 reference

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5 July 2018

Efficient gene therapy for Parkinson's disease using astrocytes as hosts for localized neurotrophic factor delivery

1 reference

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5 July 2018

Diagnosis and initiation of treatment in Parkinson's disease

1 reference

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5 July 2018

Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: support for nigral targeting in Parkinson's disease

1 reference

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5 July 2018

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1 reference

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5 July 2018

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

1 reference

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5 July 2018

Interventional MRI-guided putaminal delivery of AAV2-GDNF for a planned clinical trial in Parkinson's disease

1 reference

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5 July 2018

Anterograde axonal transport of AAV2-GDNF in rat basal ganglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Effects of intrastriatal GDNF on the response of dopamine neurons to 6-hydroxydopamine: Time course of protection and neurorestoration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Pseudotype-dependent lentiviral transduction of astrocytes or neurons in the rat substantia nigra

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

1 reference

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Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing

1 reference

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Optimal promoter usage for lentiviral vector-mediated transduction of cultured central nervous system cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Recent advances in lentiviral vector development and applications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Integrase-defective lentiviral vectors: progress and applications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Integration-deficient lentiviral vectors: a slow coming of age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Driving GDNF expression: the green and the red traffic lights

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Absolute requirement of GDNF for adult catecholaminergic neuron survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Gene delivery by lentivirus vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Stable gene transfer to muscle using non-integrating lentiviral vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Effective gene therapy with nonintegrating lentiviral vectors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Lentiviral vectors for use in the central nervous system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Gene therapy for Parkinson's disease: progress and challenges

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus).

1 reference

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5 July 2018

Targeted transgene expression in rat brain using lentiviral vectors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Gene transfer of glial cell-derived neurotrophic factor and cardiotrophin-1 protects PC12 cells from injury: involvement of the phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

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Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Preservation of a functional nigrostriatal dopamine pathway by GDNF in the intrastriatal 6-OHDA lesion model depends on the site of administration of the trophic factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

A third-generation lentivirus vector with a conditional packaging system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

5 July 2018

Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

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Challenges for gene therapy of CNS disorders and implications for Parkinson's disease therapies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

Efficient gene delivery to the adult and fetal CNS using pseudotyped non-integrating lentiviral vectors.

1 reference

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29 October 2018

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2-neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4098822

29 October 2018

Changes in function and ultrastructure of striatal dopaminergic terminals that regenerate following partial lesions of the SNpc

1 reference

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

1 reference

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The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24635742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circling behavior in rats with partial, unilateral nigro-striatal lesions: Effect of amphetamine, apomorphine, and DOPA

1 reference

https://pubmed.ncbi.nlm.nih.gov/24635742

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1089/HUM.2014.003

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Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

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Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

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