(Q33914715)

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Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

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Europe PubMed Central

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11 March 2020

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Europe PubMed Central

27 September 2020

Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time (English)

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Europe PubMed Central

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11 March 2020

1 reference

28 September 2019

macromolecular substance

1 reference

16 November 2019

DNA repair enzyme

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27 September 2020

2

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Europe PubMed Central

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11 March 2020

Sarvan Kumar Radhakrishnan

3

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11 March 2020

4

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11 March 2020

6

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11 March 2020

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Gareth J Williams

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11 March 2020

Susan P Lees-Miller

5

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11 March 2020

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20 March 2014

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11 March 2020

1 May 2014

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27 September 2020

4 references

28 September 2019

16 November 2019

Europe PubMed Central

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11 March 2020

27 September 2020

17

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11 March 2020

110-120

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11 March 2020

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

1 reference

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Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair

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XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

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Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining

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Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining

1 reference

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APLF promotes the assembly and activity of non-homologous end joining protein complexes

1 reference

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Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases

1 reference

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Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

1 reference

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Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

1 reference

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Specificity of the dRP/AP lyase of Ku promotes nonhomologous end joining (NHEJ) fidelity at damaged ends

1 reference

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Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development

1 reference

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5 July 2018

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

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A human XRCC4-XLF complex bridges DNA

1 reference

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The response to and repair of RAG-mediated DNA double-strand breaks

1 reference

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Crystallization and preliminary X-ray diffraction analysis of the human XRCC4-XLF complex

1 reference

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Double-strand break end resection and repair pathway choice

1 reference

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5 July 2018

Polynucleotide kinase and aprataxin-like forkhead-associated protein (PALF) acts as both a single-stranded DNA endonuclease and a single-stranded DNA 3' exonuclease and can participate in DNA end joining in a biochemical system

1 reference

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5 July 2018

Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

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XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

1 reference

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Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

1 reference

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ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair

1 reference

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Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

1 reference

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Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

1 reference

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1 reference

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Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

1 reference

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Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF

1 reference

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PARP-3 and APLF function together to accelerate nonhomologous end-joining

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ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

1 reference

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XLF regulates filament architecture of the XRCC4·ligase IV complex

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Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Mechanistic flexibility as a conserved theme across 3 billion years of nonhomologous DNA end-joining

1 reference

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Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

1 reference

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Crystal structure of human XLF: a twist in nonhomologous DNA end-joining

1 reference

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1 reference

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5 July 2018

APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Ku recruits XLF to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Artemis phosphorylated by DNA-dependent protein kinase associates preferentially with discrete regions of chromatin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Protein mimicry of DNA and pathway regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Human DNA ligase I completely encircles and partially unwinds nicked DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Phosphorylation of Artemis following irradiation-induced DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Nonhomologous end joining and V(D)J recombination require an additional factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Synapsis of DNA ends by DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Crystal structure of an Xrcc4-DNA ligase IV complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Ku recruits the XRCC4-ligase IV complex to DNA ends

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

SAP - a putative DNA-binding motif involved in chromosomal organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Mre11 and Ku70 interact in somatic cells, but are differentially expressed in early meiosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

5 July 2018

CryoEM and image sorting for flexible protein/DNA complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Identification of Ku70 and Ku80 homologues in Arabidopsis thaliana: evidence for a role in the repair of DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4102006

29 October 2018

Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative binding modes of Ku70-SAP domain with double strand DNA: a molecular modeling study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of interaction between Ku protein and DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FAT: a novel domain in PIK-related kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24656613

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.DNAREP.2014.02.009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24656613%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24656613%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24656613%20AND%20SRC:MED&resulttype=core&format=json

11 March 2020

ResearchGate publication ID

0 references

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