(Q33922348)

30 July 2017

title

Differences in allosteric communication pipelines in the inactive and active states of a GPCR. (English)

1 reference

G protein-coupled receptor

30 July 2017

main subject

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2

Nagarajan Vaidehi

1 reference

30 July 2017

Supriyo Bhattacharya

1

1 reference

30 July 2017

language of work or name

English

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publication date

1 July 2014

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30 July 2017

number of pages

13

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inferred from page(s)

published in

Biophysical Journal

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30 July 2017

volume

107

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30 July 2017

issue

2

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30 July 2017

page(s)

422-434

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

30 July 2017

cites work

1 reference

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Activation and dynamic network of the M2 muscarinic receptor

28 July 2018

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The role of ligands on the equilibria between functional states of a G protein-coupled receptor

28 July 2018

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The dynamic process of β(2)-adrenergic receptor activation

28 July 2018

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Restructuring G-protein- coupled receptor activation

28 July 2018

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Emerging opportunities for allosteric modulation of G-protein coupled receptors

28 July 2018

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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

28 July 2018

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

28 July 2018

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Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

28 July 2018

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Detection of allosteric signal transmission by information-theoretic analysis of protein dynamics

28 July 2018

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Activation mechanism of the β2-adrenergic receptor

28 July 2018

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

28 July 2018

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β-Arrestin-mediated receptor trafficking and signal transduction

28 July 2018

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Crystal structure of metarhodopsin II

28 July 2018

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The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

28 July 2018

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

28 July 2018

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Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach

28 July 2018

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Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles

28 July 2018

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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

28 July 2018

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Dynamic allostery in the methionine repressor revealed by force distribution analysis

28 July 2018

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Configurational entropy in protein-peptide binding: computational study of Tsg101 ubiquitin E2 variant domain with an HIV-derived PTAP nonapeptide

28 July 2018

1 reference

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Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

28 July 2018

1 reference

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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

28 July 2018

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Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization

28 July 2018

1 reference

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Structure of a beta1-adrenergic G-protein-coupled receptor

28 July 2018

1 reference

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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor

28 July 2018

1 reference

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Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form

28 July 2018

1 reference

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GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

28 July 2018

1 reference

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Contact rearrangements form coupled networks from local motions in allosteric proteins

28 July 2018

1 reference

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Signal propagation in proteins and relation to equilibrium fluctuations

28 July 2018

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G protein coupled receptor structure and activation

28 July 2018

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Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

28 July 2018

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Evolutionarily conserved networks of residues mediate allosteric communication in proteins

28 July 2018

1 reference

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Identification of an allosteric binding site for Zn2+ on the beta2 adrenergic receptor

28 July 2018

1 reference

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Ser203 as well as Ser204 and Ser207 in fifth transmembrane domain of the human beta2-adrenoceptor contributes to agonist binding and receptor activation

28 July 2018

1 reference

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Site-directed mutagenesis of beta-adrenergic receptors. Identification of conserved cysteine residues that independently affect ligand binding and receptor activation.

28 July 2018

1 reference

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Structural basis of beta-adrenergic receptor function.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Activation and allosteric modulation of a muscarinic acetylcholine receptor

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Structure of the agonist-bound neurotensin receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Allosteric pathways in imidazole glycerol phosphate synthase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Structure and dynamics of the M3 muscarinic acetylcholine receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

The role of conformational ensembles in ligand recognition in G-protein coupled receptors.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Dynamical networks in tRNA:protein complexes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Random mutagenesis of the human adenosine A2B receptor followed by growth selection in yeast. Identification of constitutively active and gain of function mutations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

The mutual information: detecting and evaluating dependencies between variables.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Mutagenesis and modelling of the alpha(1b)-adrenergic receptor highlight the role of the helix 3/helix 6 interface in receptor activation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

Beta(1)-selective agonist (-)-1-(3,4-dimethoxyphenetylamino)-3-(3,4-dihydroxy)-2-propanol [(-)-RO363] differentially interacts with key amino acids responsible for beta(1)-selective binding in resting and active states

29 October 2018

1 reference

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The forgotten serine. A critical role for Ser-2035.42 in ligand binding to and activation of the beta 2-adrenergic receptor.

29 October 2018

1 reference

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Constitutive activation of G protein-coupled receptors as a result of selective substitution of a conserved leucine residue in transmembrane helix III.

29 October 2018

1 reference

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Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4104064

The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor

29 October 2018

1 reference

12 December 2020

Site-directed mutagenesis of the rat m1 muscarinic acetylcholine receptor. Role of conserved cysteines in receptor function

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12 December 2020

Amino acids of the alpha1B-adrenergic receptor involved in agonist binding: differences in docking catecholamines to receptor subtypes

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12 December 2020

The role of the seventh transmembrane region in high affinity binding of a beta 2-selective agonist TA-2005

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12 December 2020

Structure-function analysis of the beta-adrenergic receptor

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12 December 2020

10.1016/J.BPJ.2014.06.015

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference