(Q50470980)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

title

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

G protein-coupled receptor

27 February 2020

main subject

1 reference

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Meritxell Canals

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Patrick M. Sexton

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Arthur Christopoulos

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Celine Valant

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

James R Valcourt

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

J. Robert Lane

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

11

Jonathan B Baell

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

10

Raphaël Rahmani

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

1

Ron O Dror

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

author name string

Hillary F Green

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Albert C Pan

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

Daniel H Arlow

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

David E Shaw

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

language of work or name

English

0 references

publication date

13 October 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

number of pages

5

1 reference

inferred from page(s)

published in

Nature

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

volume

503

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

issue

7475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

27 February 2020

page(s)

295-299

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/nature12595

27 February 2020

exact match

0 references

cites work

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

1 reference

12 December 2020

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

1 reference

12 December 2020

The tetrahydroisoquinoline derivative SB269,652 is an allosteric antagonist at dopamine D3 and D2 receptors

1 reference

12 December 2020

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

12 December 2020

Electrostatics of nanosystems: application to microtubules and the ribosome

1 reference

12 December 2020

Structure and dynamics of the M3 muscarinic acetylcholine receptor

1 reference

12 December 2020

Flexible ligand docking to multiple receptor conformations: a practical alternative

1 reference

12 December 2020

Structure-based drug screening for G-protein-coupled receptors

1 reference

12 December 2020

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors

1 reference

12 December 2020

Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

1 reference

12 December 2020

Selective activation of the M1 muscarinic acetylcholine receptor achieved by allosteric potentiation

1 reference

12 December 2020

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

1 reference

12 December 2020

Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

1 reference

12 December 2020

Crystal structure of metarhodopsin II

1 reference

12 December 2020

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

1 reference

12 December 2020

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis

1 reference

12 December 2020

How robust are protein folding simulations with respect to force field parameterization?

1 reference

12 December 2020

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

1 reference

12 December 2020

Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors

1 reference

12 December 2020

Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

1 reference

12 December 2020

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

1 reference

12 December 2020

How does a drug molecule find its target binding site?

1 reference

12 December 2020

Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor

1 reference

12 December 2020

Atomic-level characterization of the structural dynamics of proteins

1 reference

12 December 2020

Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.

1 reference

12 December 2020

VMD: visual molecular dynamics

1 reference

12 December 2020

Gaussian split Ewald: A fast Ewald mesh method for molecular simulation

1 reference

12 December 2020

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

12 December 2020

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

1 reference

12 December 2020

Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations.

1 reference

12 December 2020

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

1 reference

12 December 2020

Pathway and mechanism of drug binding to G-protein-coupled receptors.

1 reference

12 December 2020

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

1 reference

12 December 2020

Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands

1 reference

12 December 2020

Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors

1 reference

12 December 2020

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

1 reference

12 December 2020

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

1 reference

12 December 2020

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

1 reference

12 December 2020

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1 reference

12 December 2020

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

1 reference

12 December 2020

Allosteric Modulation of Muscarinic Acetylcholine Receptors

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

N+/Si Replacement as a Tool for Probing the Pharmacophore of Allosteric Modulators of Muscarinic M2Receptors: Synthesis, Allosteric Potency, and Positive Cooperativity of Silicon-Based W84 Derivatives

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

Millisecond-scale molecular dynamics simulations on Anton

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

221. The constitution of aspidospermine. Part III. Reactivity at the nitrogen atoms, and biogenetic considerations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

A fast SHAKE algorithm to solve distance constraint equations for small molecules in molecular dynamics simulations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

Reversible multiple time scale molecular dynamics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12595

7 January 2021

Identifiers

DOI

10.1038/NATURE12595

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24121438%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

27 February 2020

0 references

1 reference