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Activity of any class IA PI3K isoform can sustain cell proliferation and survival.
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Europe PubMed Central
PMC publication ID
2895061
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
title
Activity of any class IA PI3K isoform can sustain cell proliferation and survival
(English)
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Europe PubMed Central
PMC publication ID
2895061
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5 February 2020
author
Alexander Gray
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3
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Europe PubMed Central
PMC publication ID
2895061
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5 February 2020
Bart Vanhaesebroeck
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5
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Bart Vanhaesebroeck
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Europe PubMed Central
PMC publication ID
2895061
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
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5 February 2020
author name string
Lazaros C Foukas
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1
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Europe PubMed Central
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2895061
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
Inma M Berenjeno
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2
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2895061
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
Asim Khwaja
series ordinal
4
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Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
language of work or name
English
0 references
publication date
7 June 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
published in
Proceedings of the National Academy of Sciences of the United States of America
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Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
volume
107
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Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
issue
25
1 reference
stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
page(s)
11381-11386
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stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
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Enhanced anti-cancer effect of a phosphatidylinositol-3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status
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The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
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A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.
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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
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5 July 2018
Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers
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PubMed Central
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Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase
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5 July 2018
Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.
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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma
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5 July 2018
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5 July 2018
Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice
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The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
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5 July 2018
Biochemical characterization of the ataxia-telangiectasia mutated (ATM) protein from human cells
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5 July 2018
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5 July 2018
Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells
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5 July 2018
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5 July 2018
Immortalization of yolk sac-derived precursor cells
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5 July 2018
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation
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5 July 2018
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
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5 July 2018
New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
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5 July 2018
Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.
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5 July 2018
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.
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5 July 2018
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase
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5 July 2018
p110δ, a novel phosphoinositide 3-kinase in leukocytes
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5 July 2018
Multiple cytokines activate phosphatidylinositol 3-kinase in hemopoietic cells. Association of the enzyme with various tyrosine-phosphorylated proteins.
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5 July 2018
PIK3CA is implicated as an oncogene in ovarian cancer.
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Crossref
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21 January 2018
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
1 reference
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29 October 2018
Transforming function of the HOX11/TCL3 homeobox gene.
1 reference
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29 October 2018
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20534549
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20534549
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1073/PNAS.0906461107
1 reference
stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
ADS bibcode
2010PNAS..10711381F
0 references
PMC publication ID
2895061
1 reference
stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
PubMed publication ID
20534549
1 reference
stated in
Europe PubMed Central
PMC publication ID
2895061
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534549%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 February 2020
ResearchGate publication ID
44660160
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