(Q33966987)

English

Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Lu Peng

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Dongyu Liang

2

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Wenyan Tong

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jianhua Li

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Zhenghong Yuan

5

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

0 references

publication date

3 May 2010

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

27

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

20870-20881

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

1 reference

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mTOR signaling at a glance

1 reference

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Identification of Hepatitis C Virus NS5A Inhibitors

1 reference

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Suppression of a pro-apoptotic K+ channel as a mechanism for hepatitis C virus persistence

1 reference

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The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo

1 reference

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A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

1 reference

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Apoptosis and cancer: the genesis of a research field

1 reference

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mTOR/S6 kinase pathway contributes to astrocyte survival during ischemia

1 reference

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5 July 2018

Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition

1 reference

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5 July 2018

Apoptosis in animal models of virus-induced disease

1 reference

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5 July 2018

Hepatitis C Virus Infection Induces Apoptosis through a Bax-Triggered, Mitochondrion-Mediated, Caspase 3-Dependent Pathway

1 reference

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5 July 2018

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

FKBP family proteins: immunophilins with versatile biological functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

1 reference

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5 July 2018

Interferon signaling and treatment outcome in chronic hepatitis C

1 reference

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5 July 2018

Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death

1 reference

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5 July 2018

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Regulation of Hepatitis C Virion Production via Phosphorylation of the NS5A Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Defining the role of mTOR in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Anchoring of the 26S proteasome to the organellar membrane by FKBP38.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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Deregulation of eIF4E: 4E-BP1 in differentiated human papillomavirus-containing cells leads to high levels of expression of the E7 oncoprotein

1 reference

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5 July 2018

Non-structural protein 4A of Hepatitis C virus accumulates on mitochondria and renders the cells prone to undergoing mitochondria-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

HCV E2 may induce apoptosis of Huh-7 cells via a mitochondrial-related caspase pathway

1 reference

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The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity

1 reference

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5 July 2018

Single-point mutations of hepatitis C virus NS3 that impair p53 interaction and anti-apoptotic activity of NS3.

1 reference

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5 July 2018

Mechanism of action of interferon and ribavirin in treatment of hepatitis C

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Activation of the N-Ras-PI3K-Akt-mTOR pathway by hepatitis C virus: control of cell survival and viral replication

1 reference

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5 July 2018

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

1 reference

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5 July 2018

Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion

1 reference

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5 July 2018

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Adaptive mutations producing efficient replication of genotype 1a hepatitis C virus RNA in normal Huh7 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

The transmembrane domain of hepatitis C virus E1 glycoprotein induces cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade

1 reference

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5 July 2018

Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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Course and outcome of hepatitis C

1 reference

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Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection

1 reference

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Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

1 reference

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5 July 2018

HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Modulation of cell growth by the hepatitis C virus nonstructural protein NS5A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

1 reference

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5 July 2018

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2898342

5 July 2018

Unscrambling hepatitis C virus-host interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112045

21 January 2018

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.112045

21 January 2018

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M110.112045

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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