(Q34020622)

English

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Parkinson's disease

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Christopher A Ross

14

object named as

Christopher A Ross

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

author name string

Mali Jiang

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Yair Porat-Shliom

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Zhong Pei

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Yong Cheng

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Lan Xiang

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Katherine Sommers

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Qing Li

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Frank Gillardon

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Bastian Hengerer

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Cynthia Berlinicke

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Wanli W Smith

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Michelle A Poirier

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Wenzhen Duan

15

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

language of work or name

0 references

publication date

19 April 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Journal of Neurochemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

114

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

419-429

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

Cell death pathways in Parkinson's disease: role of mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Baicalein exerts neuroprotective effects in 6-hydroxydopamine-induced experimental parkinsonism in vivo and in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Central role of alpha-synuclein oligomers in neurodegeneration in Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Alpha-synuclein misfolding and neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Parkinson's disease: clinical features and diagnosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

The aggregation and fibrillation of alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

The alpha-synuclein mutation E46K promotes aggregation in cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Baicalein attenuates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Dopaminergic neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

The E46K mutation in alpha-synuclein increases amyloid fibril formation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Mutation E46K increases phospholipid binding and assembly into filaments of human alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Protein aggregation and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Caught in the act: alpha-synuclein is the culprit in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Mutant and wild-type alpha-synuclein interact with mitochondrial cytochrome C oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

alpha-synuclein promotes mitochondrial deficit and oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Synucleins in synaptic plasticity and neurodegenerative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Alpha-synuclein in Lewy bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

28 July 2018

The effects of the flavonoid baicalein and osmolytes on the Mg 2+ accelerated aggregation/fibrillation of carboxymethylated bovine 1SS-alpha-lactalbumin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Baicalein prevents 6-hydroxydopamine-induced dopaminergic dysfunction and lipid peroxidation in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Dopamine induces proteasome inhibition in neural PC12 cell line.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Neurodegenerative disease: amyloid pores from pathogenic mutations

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Real-time analysis of amyloid fibril formation of alpha-synuclein using a fibrillation-state-specific fluorescent probe of JC-1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Clinical characteristics of the alpha‐synuclein mutation (G209A)‐associated Parkinson's disease in comparison with other forms of familial Parkinson's disease in Greece

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Molecular mechanisms of alpha-synuclein neurodegeneration

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Baicalein attenuates methamphetamine-induced loss of dopamine transporter in mouse striatum

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Parkinson's disease: what have we learned from the genes responsible for familial forms?

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06752.X

21 January 2018

Pathology of familial Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

29 October 2018

What can we learn from genes responsible for familial forms of Parkinson's disease?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

29 October 2018

Description of Parkinson's disease as a clinical syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

29 October 2018

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

29 October 2018

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910156

29 October 2018

Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1471-4159.2010.06752.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

release_bm35x4n6ovezpnimv24czxzzky

1 reference

https://api.fatcat.wiki/v0/release/bm35x4n6ovezpnimv24czxzzky

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20412383%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q34020622&oldid=1843389132"