(Q34036136)

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Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Kevin Yarasheski

13

object named as

Kevin E Yarasheski

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Randall J. Bateman

object named as

Randall J Bateman

14

0 references

author name string

Jacquelynn J Cook

1

1 reference

Europe PubMed Central

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30 July 2017

Kristin R Wildsmith

2

1 reference

Europe PubMed Central

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30 July 2017

David B Gilberto

3

1 reference

Europe PubMed Central

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30 July 2017

Marie A Holahan

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Gene G Kinney

5

1 reference

Europe PubMed Central

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30 July 2017

Parker D Mathers

6

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Maria S Michener

7

1 reference

Europe PubMed Central

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30 July 2017

Eric A Price

8

1 reference

Europe PubMed Central

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30 July 2017

Mark S Shearman

9

1 reference

Europe PubMed Central

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30 July 2017

Adam J Simon

10

1 reference

Europe PubMed Central

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30 July 2017

Jennifer X Wang

11

1 reference

Europe PubMed Central

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30 July 2017

Guoxin Wu

12

1 reference

Europe PubMed Central

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30 July 2017

language of work or name

0 references

publication date

1 May 2010

1 reference

Europe PubMed Central

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30 July 2017

Journal of Neuroscience

1 reference

Europe PubMed Central

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30 July 2017

30

1 reference

Europe PubMed Central

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30 July 2017

19

1 reference

Europe PubMed Central

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30 July 2017

6743-6750

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

A novel pathway for amyloid precursor protein processing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Secretase inhibitors and modulators for Alzheimer's disease treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

A gamma-secretase inhibitor decreases amyloid-beta production in the central nervous system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Selective amyloid-beta lowering agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Intramembrane proteolysis by gamma-secretase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Inhibition and modulation of gamma-secretase for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Measuring target effect of proposed disease-modifying therapies in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Stable isotope labeling tandem mass spectrometry (SILT) to quantify protein production and clearance rates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Direct regulation of intestinal fate by Notch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Transgenic mouse models of Alzheimer's disease: how useful have they been for therapeutic development?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

BACE1: the beta-secretase enzyme in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Senile plaques in cortex of aged normal monkeys.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

Measurement of muscle protein fractional synthetic rate by capillary gas chromatography/combustion isotope ratio mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

5 July 2018

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Safety, tolerability, and changes in amyloid beta concentrations after administration of a gamma-secretase inhibitor in volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2913973

29 October 2018

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20463236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An alternative method of chronic cerebrospinal fluid collection via the cisterna magna in conscious rhesus monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/20463236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch and the immune system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20463236

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1381-10.2010

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

release_ooe2n33mebhtzobxtd6w24nr2y

1 reference

https://api.fatcat.wiki/v0/release/ooe2n33mebhtzobxtd6w24nr2y

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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