(Q34046583)

30 July 2017

1 reference

title

Mysterious oligomerization of the amyloidogenic proteins (English)

1 reference

30 July 2017

1

Vladimir N Uversky

1 reference

30 July 2017

language of work or name

English

0 references

publication date

10 June 2010

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30 July 2017

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30 July 2017

volume

277

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30 July 2017

issue

14

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30 July 2017

page(s)

2940-2953

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Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

30 July 2017

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation

5 July 2018

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5 July 2018

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5 July 2018

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Smoking and Parkinson's disease: does nicotine affect alpha-synuclein fibrillation?

5 July 2018

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5 July 2018

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Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein

5 July 2018

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Structural classification of toxic amyloid oligomers

5 July 2018

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A soluble oligomer of tau associated with fiber formation analyzed by NMR.

5 July 2018

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Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

5 July 2018

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Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

5 July 2018

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5 July 2018

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Branched chain mechanism of polymerization and ultrastructure of prion protein amyloid fibrils

28 October 2018

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Assembly of two distinct dimers and higher-order oligomers from full-length tau.

5 July 2018

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5 July 2018

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Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

5 July 2018

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A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

5 July 2018

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Polymorphism in the intermediates and products of amyloid assembly

5 July 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

5 July 2018

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Plasticity of amyloid fibrils

5 July 2018

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Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

5 July 2018

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Autophagy in neurodegenerative disease: friend, foe or turncoat?

5 July 2018

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Protein misfolding, functional amyloid, and human disease

5 July 2018

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A specific amyloid-beta protein assembly in the brain impairs memory

5 July 2018

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Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

5 July 2018

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Structuring the puzzle of prion propagation

5 July 2018

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Early events in insulin fibrillization studied by time-lapse atomic force microscopy

5 July 2018

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Sick chaperones, cellular stress, and disease

5 July 2018

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5 July 2018

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Tau suppression in a neurodegenerative mouse model improves memory function

5 July 2018

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Alzheimer's disease: Abeta, tau and synaptic dysfunction

5 July 2018

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

5 July 2018

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Modulation of neurodegeneration by molecular chaperones

5 July 2018

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Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain

5 July 2018

1 reference

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Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

alpha-Synuclein locus triplication causes Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Molecular mechanisms of amyloidosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Pathological peptide folding in Alzheimer's disease and other conformational disorders

5 July 2018

1 reference

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Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Therapeutic strategies for human amyloid diseases

5 July 2018

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

5 July 2018

1 reference

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

The solution structure of human β2-microglobulin reveals the prodromes of its amyloid transition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Membrane-bound alpha-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form

5 July 2018

1 reference

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Transthyretin amyloidosis: a tale of weak interactions.

5 July 2018

1 reference

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Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Amyloid fibrillogenesis: themes and variations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

5 July 2018

1 reference

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Protein misfolding, evolution and disease

5 July 2018

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Biological activity and pathological implications of misfolded proteins.

5 July 2018

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5 July 2018

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

On the nucleation and growth of amyloid beta-protein fibrils: detection of nuclei and quantitation of rate constants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2916643

Recombinant immunoglobulin variable domains generated from synthetic genes provide a system for in vitro characterization of light-chain amyloid proteins

5 July 2018

1 reference

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Kinetic studies on photolysis-induced gelation of sickle cell hemoglobin suggest a new mechanism

5 July 2018

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Self-replication and scrapie

5 July 2018

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Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease?

5 July 2018

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Clinical implications of monoclonal light chains

5 July 2018

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Amyloid fibril protein nomenclature -- 2002.

5 July 2018

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Association between cardiac denervation and parkinsonism caused by alpha-synuclein gene triplication

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations

21 January 2018

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Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

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Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).

21 January 2018

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Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

21 January 2018

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The molecular basis of amyloidosis.

21 January 2018

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Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid.

21 January 2018

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Structural and Conformational Prerequisites of Amyloidogenesis

21 January 2018

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Analysis of protein aggregation kinetics.

21 January 2018

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Fragmentation of actin filaments.

21 January 2018

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Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

21 January 2018

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Stabilization of partially folded conformation during alpha-synuclein oligomerization in both purified and cytosolic preparations

21 January 2018

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Annular alpha-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes

21 January 2018

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Conformational behavior and aggregation of alpha-synuclein in organic solvents: modeling the effects of membranes

21 January 2018

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Rapid self-assembly of alpha-synuclein observed by in situ atomic force microscopy

21 January 2018

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Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

21 January 2018

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Effects of nitration on the structure and aggregation of alpha-synuclein

21 January 2018

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Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation

21 January 2018

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Evidence for stepwise formation of amyloid fibrils by the mouse prion protein

21 January 2018

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Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism

21 January 2018

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Early events in the fibrillation of monomeric insulin.

21 January 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

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Multiple assembly pathways underlie amyloid-beta fibril polymorphisms

21 January 2018

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12 December 2020

alpha-Synuclein membrane interactions and lipid specificity

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12 December 2020

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12 December 2020

Secondary structure of alpha-synuclein oligomers: characterization by raman and atomic force microscopy

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12 December 2020

The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain

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12 December 2020

Dityrosine cross-linking promotes formation of stable alpha -synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies

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Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference