(Q34055963)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

7

1 reference

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4 February 2020

author name string

J Jefferson P Perry

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Aroumougame Asaithamby

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Adam Barnebey

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Foad Kiamanesch

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

David J Chen

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Seungil Han

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

Steven M Yannone

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

language of work or name

English

0 references

publication date

1 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

4 February 2020

published in

1 reference

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4 February 2020

volume

285

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

issue

33

1 reference

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4 February 2020

page(s)

25699-25707

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

4 February 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2919133/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends

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Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.

5 July 2018

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Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

5 July 2018

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Molecular insights into the recruitment of TFIIH to sites of DNA damage

5 July 2018

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Flipping of alkylated DNA damage bridges base and nucleotide excision repair

5 July 2018

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Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence

5 July 2018

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Structure of the human RECQ1 helicase reveals a putative strand-separation pin

5 July 2018

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Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair

5 July 2018

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DNA-PK: the means to justify the ends?

5 July 2018

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

5 July 2018

1 reference

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The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

5 July 2018

1 reference

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Werner Syndrome, aging and cancer

5 July 2018

1 reference

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The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Structure and function of the regulatory C-terminal HRDC domain from Deinococcus radiodurans RecQ

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

DNA apurinic-apyrimidinic site binding and excision by endonuclease IV

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Crystal structure of the HRDC domain of human Werner syndrome protein, WRN

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair

5 July 2018

1 reference

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Conferring substrate specificity to DNA helicases: role of the RecQ HRDC domain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The design of coiled-coil structures and assemblies

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The life and death of DNA-PK.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Scaffolds, levers, rods and springs: diverse cellular functions of long coiled-coil proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Clinical features of Bloom syndrome and function of the causative gene, BLM helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Coiled coil domains: stability, specificity, and biological implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

High-resolution structure of the E.coli RecQ helicase catalytic core

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Characterization and mutational analysis of the RecQ core of the bloom syndrome protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Drosophila melanogaster RECQ5/QE DNA helicase: stimulation by GTP binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Protein phosphatases regulate DNA-dependent protein kinase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Chromosomal stability and the DNA double-stranded break connection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner's syndrome cell lines are hypersensitive to camptothecin-induced chromosomal damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Spontaneous and X-ray-induced chromosomal aberrations in Werner syndrome cells detected by FISH using chromosome-specific painting probes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Functional interaction between Ku and the werner syndrome protein in DNA end processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Characterization of the human and mouse WRN 3'-->5' exonuclease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Ku complex interacts with and stimulates the Werner protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

DNA-bound structures and mutants reveal abasic DNA binding by APE1 and DNA repair coordination [corrected]

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Substrate specificities and identification of putative substrates of ATM kinase family members

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Cell fusion corrects the 4-nitroquinoline 1-oxide sensitivity of Werner syndrome fibroblast cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Oligomeric ring structure of the Bloom's syndrome helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Werner syndrome protein. I. DNA helicase and dna exonuclease reside on the same polypeptide.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

The Werner syndrome protein is a DNA helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Positional cloning of the Werner's syndrome gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

DNA damage and the DNA-activated protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Mutator phenotype of Werner syndrome is characterized by extensive deletions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

Predicting coiled coils from protein sequences

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2919133

An HMM model for coiled-coil domains and a comparison with PSSM-based predictions.

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.124941

The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.124941

The Escherichia coli RecQ helicase functions as a monomer

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M110.124941

Purification of overexpressed hexahistidine-tagged BLM N431 as oligomeric complexes

21 January 2018

1 reference

12 December 2020

Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation

1 reference

12 December 2020

Lack of WRN results in extensive deletion at nonhomologous joining ends

1 reference

12 December 2020

A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

1 reference

12 December 2020

NMR assignments of the winged-helix domain of human werner syndrome protein

1 reference

12 December 2020

Werner syndrome protein. II. Characterization of the integral 3' --> 5' DNA exonuclease

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.124941

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516064%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

PubMed publication ID

20516064

1 reference