(Q34075028)

30 July 2017

1 reference

title

Cyclin-dependent kinase inhibitors: novel anticancer agents (English)

1 reference

30 July 2017

Mani S

1

1 reference

30 July 2017

Wang C

2

1 reference

30 July 2017

Wu K

3

1 reference

30 July 2017

Francis R

4

1 reference

30 July 2017

Pestell R

5

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 August 2000

1 reference

Expert Opinion on Investigational Drugs

30 July 2017

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30 July 2017

9

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30 July 2017

1849-1870

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30 July 2017

8

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The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation

30 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

CDC25 phosphatases as potential human oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

New functional activities for the p21 family of CDK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Induction of cyclin D1 by simian virus 40 small tumor antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclin D1 provides a link between development and oncogenesis in the retina and breast.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Temporal and spatial control of cyclin B1 destruction in metaphase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Inhibition of cyclin-dependent kinases by p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The role of p16-cyclin d/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

High prevalence of p16 genetic alterations in head and neck tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Preclinical and clinical development of cyclin-dependent kinase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Chemical inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Potent interaction of flavopiridol with MRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

In vitro evaluation of flavopiridol, a novel cell cycle inhibitor, in bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Phase I trial of continuous infusion flavopiridol, a novel cyclin-dependent kinase inhibitor, in patients with refractory neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Overproduction of protein kinase C causes disordered growth control in rat fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Protein kinase C isozyme-mediated cell cycle arrest involves induction of p21(waf1/cip1) and p27(kip1) and hypophosphorylation of the retinoblastoma protein in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cell division arrest induced by phorbol ester in CHO cells overexpressing protein kinase C-delta subspecies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

28 Use and specificity of staurosporine, UCN-O1, and calphostin C as protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

UCN-01 abrogates G2 arrest through a Cdc2-dependent pathway that is associated with inactivation of the Wee1Hu kinase and activation of the Cdc25C phosphatase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cyclin-dependent kinases: initial approaches to exploit a novel therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

6-Dimethylaminopurine blocks starfish oocyte maturation by inhibiting a relevant protein kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Multiple modes of ligand recognition: crystal structures of cyclin-dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

In vivo protein transduction: delivery of a biologically active protein into the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The acetyltransferase activity of CBP stimulates transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The CBP co-activator is a histone acetyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

The transcriptional coactivators p300 and CBP are histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Histone deacetylase: a regulator of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Histone acetylation and transcriptional regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

What's up and down with histone deacetylation and transcription?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Gene activation by histone and factor acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Histone deacetylase inhibitors: novel anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

Dual control of mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

A growing coactivator network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.9.8.1849

UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.42.571

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.40.1782

Identifiers

DOI

10.1517/13543784.9.8.1849

1 reference

30 July 2017

1 reference