(Q34082976)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

OJDXPBWKOFNPDR-YTQOOTMVSA-N

1 reference

inferred from

reverse claim

author

Alessandra S Eustáquio

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

author name string

Jeffrey E Janso

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Anokha S Ratnayake

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Christopher J O'Donnell

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

Frank E Koehn

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

language of work or name

English

0 references

publication date

5 August 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

12 March 2020

https://www.pnas.org/content/pnas/111/33/E3376.full.pdf

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.1408300111?email=unpaywall_01@example.com

published in

Proceedings of the National Academy of Sciences of the United States of America

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

volume

111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

issue

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

page(s)

E3376-85

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

19 March 2024

https://api.unpaywall.org/v2/10.1073/pnas.1408300111?email=unpaywall_01@example.com

access restriction status

open access

1 reference

inferred from online access status

cites work

Pre-mRNA splicing-modulatory pharmacophores: the total synthesis of herboxidiene, a pladienolide-herboxidiene hybrid analog and related derivatives

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Coherence between cellular responses and in vitro splicing inhibition for the anti-tumor drug pladienolide B and its analogs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Phase I pharmacokinetic and pharmacodynamic study of the first-in-class spliceosome inhibitor E7107 in patients with advanced solid tumors.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Remediating cancer via splicing modulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Stabilized cyclopropane analogs of the splicing inhibitor FD-895

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

The spliceosome as a target of novel antitumour drugs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Baeyer-Villiger C-C bond cleavage reaction in gilvocarcin and jadomycin biosynthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Flavoenzymes: versatile catalysts in biosynthetic pathways

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Splicing in oncogenesis and tumor suppression

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Identification of the herboxidiene biosynthetic gene cluster in Streptomyces chromofuscus ATCC 49982.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Biosynthesis of polyketides by trans-AT polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

PKS and NRPS release mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Revisiting the modularity of modular polyketide synthases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Recovery of a Burkholderia thailandensis-like isolate from an Australian water source

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

An improved system for gene replacement and xylE fusion analysis in Pseudomonas aeruginosa

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Herboxidiene, a new herbicidal substance from Streptomyces chromofuscus A7847. Taxonomy, fermentation, isolation, physico-chemical and biological properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Splicing factor SF3b as a target of the antitumor natural product pladienolide.

5 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

An enzymatic domain for the formation of cyclic ethers in complex polyketides

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Cis-Double bond formation by thioesterase and transfer by ketosynthase in FR901464 biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1408300111

Isolation and characterization of a new 12-membered macrolide FD-895

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143056

Substrate specificity in ketosynthase domains from trans-AT polyketide synthases

28 October 2018

1 reference

12 December 2020

Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents

1 reference

12 December 2020

FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues

1 reference

12 December 2020

Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. II. Physico-chemical properties and structure elucidation

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action

1 reference

12 December 2020

New antitumor substances, FR901463, FR901464 and FR901465. III. Structures of FR901463, FR901464 and FR901465

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.1408300111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25097259

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25097259%20AND%20SRC:MED&resulttype=core&format=json