(Q34110442)

English

Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Liyi Geng

1

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Amelia M Huehls

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Jill M Wagner

3

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Catherine J Huntoon

4

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Europe PubMed Central

PubMed publication ID

31 July 2017

Larry M Karnitz

5

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

15 December 2011

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Europe PubMed Central

PubMed publication ID

31 July 2017

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

e28862

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

copyright license

Creative Commons Attribution 4.0 International

15 December 2011

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April 2022 Public Data File from Crossref

copyright status

0 references

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

1 reference

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1 reference

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Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.

1 reference

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Cancer statistics, 2010

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5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency

1 reference

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Microsatellite instability in colorectal cancer

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Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

1 reference

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PARP inhibition: PARP1 and beyond

1 reference

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Targeting DNA double-strand break repair: is it the right way for sensitizing cells to 5-fluorouracil?

1 reference

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Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors

1 reference

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Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

1 reference

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Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Clinical implications of microsatellite instability in sporadic colon cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Cisplatin-induced DNA damage activates replication checkpoint signaling components that differentially affect tumor cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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The role of floxuridine in metastatic liver disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Participation of DNA repair in the response to 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Uracil in DNA: consequences for carcinogenesis and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

The RNA exosome component hRrp6 is a target for 5-fluorouracil in human cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

DNA repair deficiency as a therapeutic target in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Evidence that tRNA modifying enzymes are important in vivo targets for 5-fluorouracil in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

The ATR pathway: fine-tuning the fork

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

ATM activation and DNA damage response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

The DNA N-glycosylase MED1 exhibits preference for halogenated pyrimidines and is involved in the cytotoxicity of 5-iododeoxyuridine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

Role of DNA mismatch repair in apoptotic responses to therapeutic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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1 reference

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Chromosomal instability at common fragile sites in Seckel syndrome

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1 reference

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells.

1 reference

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1 reference

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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Mutations of GTBP in genetically unstable cells

1 reference

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Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

5 July 2018

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

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Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

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A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

21 January 2018

Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

21 January 2018

Intraperitoneal mitoxantrone or floxuridine: effects on time-to-failure and survival in patients with minimal residual ovarian cancer after second-look laparotomy--a randomized phase II study by theSouthwest Oncology Group.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

21 January 2018

Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0028862

21 January 2018

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3240632

28 October 2018

Mechanism for exclusion of 5-fluorouracil from DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

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based on heuristic

inferred from PubMed ID database lookup

Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

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based on heuristic

inferred from PubMed ID database lookup

Specific inhibition of pre-ribosomal RNA processing in extracts from the lymphosarcoma cells treated with 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose 5-fluorouracil and leucovorin as second-line chemotherapy in patients with platinum-resistant epithelial ovarian cancer

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https://pubmed.ncbi.nlm.nih.gov/22194930

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based on heuristic

inferred from PubMed ID database lookup

Personalizing therapy for ovarian cancer: BRCAness and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

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based on heuristic

inferred from PubMed ID database lookup

Molecular genetics of colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22194930

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0028862

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

2011PLoSO...628862G

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

ResearchGate publication ID

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